0000000000248048
AUTHOR
Florian Länger
The bronchial circulation in COVID-19 pneumonia.
American journal of respiratory and critical care medicine : AJRCCM 205(1), 121-125 (2022). doi:10.1164/rccm.202103-0594IM
Bacitracin and Rutin Regulate Tissue Factor Production in Inflammatory Monocytes and Acute Myeloid Leukemia Blasts
Simple Summary Aberrant tissue factor (TF) expression by transformed myeloblasts and inflammatory monocytes contributes to coagulation activation in acute myeloid leukemia (AML). TF procoagulant activity (PCA) is regulated by protein disulfide isomerase (PDI), an oxidoreductase with chaperone activity, but its specific role in AML-associated TF biology is unclear. Here, we provide novel mechanistic insights into this interrelation. We show that bacitracin and rutin, two pan-inhibitors of the PDI family, prevent lipopolysaccharide (LPS)-induced monocyte TF production under inflammatory conditions and constitutive TF expression by THP1 cells and AML blasts, thus exerting promising anticoagula…
3D virtual histopathology of cardiac tissue from Covid-19 patients based on phase-contrast X-ray tomography
eLife 10, e71359 (2021). doi:10.7554/eLife.71359
Die Entwicklung der Myelofibrose bei der "präfibrotischen"cIMF
Zusammenfassung Wegen des erst kurzlich mit Erscheinen der neuen WHO-Klassifikation der chronischen myeloproliferativen Erkrankungen (CMPE) aufgegebenen Festhaltens an einer Knochenmarksfibrose als wesentliches Merkmal der chronischen idiopathischen Myelofibrose (cIMF) sind Verlaufsuntersuchungen zu der Entwicklung einer Myelofibrose (MF) bei dieser Entitat nur von fibrotischen Stadien mit widerspruchlichen Ergebnissen bekannt. Deshalb wurde eine retrospektive Studie an Verlaufsbiopsien von 38 Patienten mit cIMF ohne initiale Fibrose mit der Frage nach der Haufigkeit, der Geschwindigkeit sowie dem Ausmas der Entwicklung einer MF durchgefuhrt. Unabhangig von einer Chemotherapie fanden wir ei…
Management and Outcomes of Patients with Isolated Superficial Vein Thrombosis under Real Life Conditions (INSIGHTS-SVT).
Objective Management and outcomes of superficial vein thrombosis (SVT) are highly variable and not well described. Therefore, the INvestigating SIGnificant Health TrendS in the management of SVT (INSIGHTS-SVT) study collected prospective data under real life conditions. Methods Prospective observational study of objectively confirmed acute isolated SVT. The primary outcome was a composite of symptomatic deep vein thrombosis (DVT), pulmonary embolism (PE), and extension or recurrence of SVT at three months. The primary safety outcome was clinically relevant bleeding. Results A total of 1 150 patients were included (mean age 60.2 ± 14.7 years; 64.9% women; mean BMI 29.4 ± 6.3 kg/m2). SVT was …
3D virtual Histopathology of Cardiac Tissue from Covid-19 Patients based on Phase-Contrast X-ray Tomography
X-ray phase-contrast tomography datasets of formalin fixed paraffin embedded unstained cardiac tissue from Covid-19 patients as well as from control tissue. For each group one overview scan of the entire biopsy (3.5mm cross section) from binning and stitching different tomograms (PB bin2, voxel size: 1.3µm) as well as the respective laboratory data (LJ, voxel size: 2µm, tissue masked) and a cone-beam zoom tomogram recorded with waveguide illumination (WG, voxel size: 159 nm) is uploaded. Further datasets can be provided on request. The data has been recorded at the institute for X-ray physics (Göttingen, Germany) and DESY at the GINIX instrument, beamline P10 of the PETRAII…