0000000000261233
AUTHOR
O. Schreiner
Acute renal failure and liver dysfunction after subcutaneous injection of 3-sn-phosphatidylcholine (Lipostabil®)-case report.
INTRODUCTION Drug-induced tubulointerstitial nephritis and acute tubular necrosis are common, and are often caused by drugs especially antibiotics or non-steroidal anti-inflammatory drugs. Drug-induced liver dysfunction and renal failure after subcutaneous injection of phosphatidylcholine was not reported so far. 3-sn-Phosphatidylcholine has been described as a cell lysis reaction-inducing drug. Its in vitro data indicated a relevant toxicity potential. In particular human cell types such as fibroblast-like preadipocytes, vascular and skeletal muscle cells, or renal epithelial cells react more sensitive than other human cell types. CASE REPORT We present a 28-year-old woman who received 3.5…
„Do not rescuscitate“ – Auswirkungen der Einführung eines standardisierten Formulars auf Therapiebegrenzungen in der klinischen Praxis
Hintergrund | Wahrend DNR-Anordnungen seit den 1970 er Jahren international Verwendung finden, gibt es aus Deutschland hierzu nur wenige Daten. Demgegenuber steht die zunehmende gesetzliche Ausrichtung auf den Patientenwillen. Ziel dieser Untersuchung war es, die Haufigkeit und Qualitat von DNR-Anordnungen in einer deutschen Universitatsklinik und mogliche Veranderungen durch die Einfuhrung eines DNR-Formulars zu erfassen. Methoden | In zwei Pravalenzerhebungen wurden alle stationaren Patienten der internistischen Kliniken bezuglich DNR-Anordnungen uberpruft. Im Rahmen von zwei Mitarbeiterbefragungen wurden Pflegende und Arzte personlich angeschrieben. Weiterhin wurden alle Akten der Versto…
The Programmed Death (PD)‐1/PD‐Ligand 1 Pathway Regulates Graft‐Versus‐Host‐Reactive CD8 T Cells After Liver Transplantation
Acute graft-versus-host disease (aGVHD) is a life-threatening complication after solid-organ transplantation, which is mediated by host-reactive donor T cells emigrating from the allograft. We report on two liver transplant recipients who developed an almost complete donor chimerism in peripheral blood and bone marrow-infiltrating T cells during aGVHD. By analyzing these T cells directly ex vivo, we found that they died by apoptosis over time without evidence of rejection by host T cells. The host-versus-donor reactivity was selectively impaired, as anti-third-party and antiviral T cells were still detectable in the host repertoire. These findings support the acquired donor-specific allotol…