Hierarchical cross-scale analysis identifies parallel ventral striatal networks coding for dynamic and stabilized olfactory reward predictions
SUMMARYThe unbiased identification of brain circuits responsible for behavior and their local cellular computations is a challenge for neuroscience. We establish here a hierarchical cross-scale approach from behavioral modeling and fMRI in task-performing mice to cellular network dynamics to identify how reward predictions are represented in the forebrain upon olfactory conditioning. fMRI identified functional segregation in reward prediction and error computations among olfactory cortices and subcortical circuits. Among them, the olfactory tubercle contributed both to dynamic reward predictions and prediction error. In this region, cellular recordings revealed two parallel neuronal populat…
Large-scale network functional interactions during distraction and reappraisal in remitted bipolar and unipolar patients.
Objectives The human brain is organized into large-scale networks that dynamically interact with each other. Extensive evidence has shown characteristic changes in certain large-scale networks during transitions from internally directed to externally directed attention. The aim of the present study was to compare these context-dependent network interactions during emotion regulation and to examine potential alterations in remitted unipolar and bipolar disorder patients. Methods We employed a multi-region generalized psychophysiological interactions analysis to quantify connectivity changes during distraction vs reappraisal pair-wise across 90 regions placed throughout the four networks of i…
Sensorik Inventar (SI) – Selbstbeurteilung der sensorischen Sensitivität für Erwachsene und Jugendliche
ZusammenfassungEine adäquate Wahrnehmung der Umwelt repräsentiert eine der Grundvoraussetzungen adaptiven Verhaltens. Gleichzeitig existieren individuelle Unterschiede in der sensorischen Sensitivität, die wiederum eine zentrale Rolle bei der Entstehung und Aufrechterhaltung diverser psychischer Störungen spielen können. Die Fragestellung war die Entwicklung eines Fragebogens zur multidimensionalen Erfassung von sensorischer Sensitivität. Das Sensorik Inventar (SI) wurde von 1417 Personen ausgefüllt. Die faktorielle Validität wurde mit Hilfe explorativer Faktorenanalysen sowie mit Exploratory-Structural-Equation-Modeling überprüft. Es ergab sich eine 6-faktorielle Struktur und eine hohe int…