0000000000268734

AUTHOR

Cristina Messa 1

showing 2 related works from this author

DVWA gene polymorphisms and osteoarthritis

2015

Background: Osteoarthritis (OA) is a degenerative joints disorder influenced by genetic predisposition. We reported that rs11718863 DVWA SNP was represented in Sicilian with a more severe Kellgren and Lawrence (KL) radiographic grade, displaying its predictive role as OA marker progression. Here, we describe the DVWA SNPs: rs11718863, rs7639618, rs7651842, rs7639807 and rs17040821 probably able to induce protein functional changes. Findings: Sixty-one Sicilian patients with knee OA and 100 healthy subjects were enrolled. Clinical and radiographic evaluation was performed using AKSS scores and KL. Linkage Disequilibrium (LD) analyses were performed in order to verify whether the SNPs segrega…

MaleLinkage disequilibriumShort ReportSingle-nucleotide polymorphismOsteoarthritisCollagen Type VIBioinformaticsPolymorphism Single NucleotideGeneral Biochemistry Genetics and Molecular BiologyLinkage DisequilibriumWhite PeopleGene FrequencyOsteoarthritisHaplotypeGenetic predispositionDVWAMedicineSNPHumansGenetic Predisposition to DiseaseAlleleOsteoarthritis DVWA Single nucleotide polymorphisms Haplotypes KLAllele frequencySicilyAllelesAgedMedicine(all)Aged 80 and overBiochemistry Genetics and Molecular Biology(all)business.industryHaplotypeHomozygoteGeneral MedicineSingle nucleotide polymorphismsMiddle AgedOsteoarthritis Kneemedicine.diseaseSingle nucleotide polymorphismKLHaplotypesOsteoarthritiFemalebusinessPseudogenesBMC Research Notes
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High-Intensity Focused Ultrasound- and Radiation Therapy-Induced Immuno-modulation: Comparison and Potential Opportunities

2017

In recent years, high-intensity focused ultrasound (HIFU) has emerged as a new and promising non-invasive and non-ionizing ablative technique for the treatment of localized solid tumors. Extensive pre-clinical and clinical studies have evidenced that, in addition to direct destruction of the primary tumor, HIFU-thermoablation may elicit long-term systemic host anti-tumor immunity. In particular, an important consequence of HIFU treatment includes the release of tumor-associated antigens (TAAs), the secretion of immuno-suppressing factors by cancer cells and the induction of cytotoxic T lymphocyte (CTL) activity. Radiation therapy (RT) is the main treatment modality used for many types of tu…

0301 basic medicinePathologymedicine.medical_specialtyRadiology Nuclear Medicine and ImagingAcoustics and Ultrasonicsmedicine.medical_treatmentBiophysicsImmunomodulation03 medical and health sciences0302 clinical medicineImmune systemNeoplasmsmedicineBystander effectHumansCancerChemotherapyRadiological and Ultrasound Technologybusiness.industryCancermedicine.diseasePrimary tumorThermal ablationHigh-intensity focused ultrasoundRadiation therapyImmuno-therapyRadiation therapyTumor vaccine030104 developmental biologyBiophysicHigh-intensity focused ultrasound030220 oncology & carcinogenesisCancer cellCancer researchHigh-Intensity Focused Ultrasound AblationAnti-tumor immunitybusinessAnti-tumor immunity; Cancer; High-intensity focused ultrasound; Immuno-therapy; Radiation therapy; Thermal ablation; Tumor vaccine
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