0000000000275460

AUTHOR

Clemens K. Weiss

showing 2 related works from this author

Large area conductive nanoaperture arrays with strong optical resonances and spectrally flat terahertz transmission

2017

Using simple and inexpensive nanosphere lithography, we produce large, centimeter-squared sized thin golden films patterned with a hexagonal array of nanoapertures with controllable dimensions on the order of 100–300 nm, spaced by a 350–375 nm pitch distance. The optical transmission spectra of our samples are dominated by the resonant plasmonic features in the spectral range 500–700 nm, caused by the nanostructure in the film. At the same time, the transmission at terahertz (THz) radiation is as high as ∼10% and is spectrally flat. Our measurements are in agreement with finite difference time domain simulations. Such thin metal hole array films allow for very efficient injection of optical…

0301 basic medicineNanostructureMaterials sciencePhysics and Astronomy (miscellaneous)Terahertz radiationbusiness.industryNanophotonicsFinite-difference time-domain methodPhysics::Optics02 engineering and technologyPhysik (inkl. Astronomie)021001 nanoscience & nanotechnology03 medical and health sciences030104 developmental biologyNanolithographyOpticsTransmission (telecommunications)OptoelectronicsNanosphere lithography0210 nano-technologybusinessPlasmonApplied Physics Letters
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Nanoprobing the acidification process during intracellular uptake and trafficking

2015

Abstract Many nanoparticular drug delivery approaches rely on a detailed knowledge of the acidification process during intracellular trafficking of endocytosed nanoparticles (NPs). Therefore we produced a nanoparticular pH sensor composed of the fluorescent pH-sensitive dual wavelength dye carboxy seminaphthorhodafluor-1 (carboxy SNARF-1) coupled to the surface of amino-functionalized polystyrene NPs (SNARF-1-NP). By applying a calibration fit function to confocal laser scanning microscopy (CLSM) images, local pH values were determined. The acidification and ripening process of endo/lysosomal compartments containing nanoparticles was followed over time and was found to progress up to 6h to …

Biomedical EngineeringPharmaceutical ScienceMedicine (miscellaneous)NanoparticleBioengineeringNaphtholsPh changesHumansBenzopyransGeneral Materials ScienceDual wavelengthNanoprobingRhodaminesChemistryBiological TransportHydrogen-Ion ConcentrationFluorescenceEndocytosisNanostructuresCell biologyTransmission electron microscopyMolecular ProbesCalibrationDrug deliveryMolecular MedicineAcidsIntracellularHeLa CellsNanomedicine: Nanotechnology, Biology and Medicine
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