0000000000281645

AUTHOR

Olga González-lopez

showing 3 related works from this author

The PHES battery does not detect all cirrhotic patients with early neurological deficits, which are different in different patients.

2017

Background and aims The psychometric hepatic encephalopathy score (PHES) is the “gold standard” for minimal hepatic encephalopathy (MHE) diagnosis. Some reports suggest that some cirrhotic patients “without” MHE according to PHES show neurological deficits and other reports that neurological alterations are not homogeneous in all cirrhotic patients. This work aimed to assess whether: 1) a relevant proportion of cirrhotic patients show neurological deficits not detected by PHES; 2) cirrhotic patients with mild neurological deficits are a homogeneous population or may be classified in sub-groups according to specific deficits. Methods Cirrhotic patients “without” (n = 56) or “with” MHE (n = 4…

Liver CirrhosisMalePathologyPediatricsCirrhosisPsychometricsSocial Scienceslcsh:MedicineNeuropsychological Tests0302 clinical medicineMedicine and Health SciencesPsychologyCluster AnalysisAttentionlcsh:ScienceHepatic encephalopathyCognitive Impairmenteducation.field_of_studyMultidisciplinaryCognitive NeurologyLiver DiseasesMiddle AgedNeurologyCirrhosisOncologyFemale030211 gastroenterology & hepatologyResearch Articlemedicine.medical_specialtyPsychometricsCognitive NeurosciencePopulationGastroenterology and HepatologyCarcinomas03 medical and health sciencesNeuropsychologyGastrointestinal TumorsmedicineHumanseducationNeuropsychological TestingAgedWorking memorybusiness.industryGold standardlcsh:RCognitive PsychologyCase-control studyBiology and Life SciencesCancers and NeoplasmsReproducibility of ResultsHepatocellular Carcinomamedicine.diseasePatient Outcome AssessmentCase-Control StudiesHepatic EncephalopathyStroop TestCognitive Sciencelcsh:QbusinessPsychomotor Performance030217 neurology & neurosurgeryNeuroscienceFollow-Up StudiesStroop effectPLoS ONE
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Patients with minimal hepatic encephalopathy show impaired mismatch negativity correlating with reduced performance in attention tests

2012

Attention deficit is an early event in the cognitive impairment of patients with minimal hepatic encephalopathy (MHE). The underlying mechanisms remain unclear. Mismatch negativity (MMN) is an auditory event-related potential that reflects an attentional trigger. Patients with schizophrenia show impaired attention and cognitive function, which are reflected in altered MMN. We hypothesized that patients with MHE, similarly to those with schizophrenia, should show MMN alterations related with attention deficits. The aims of this work were to assess whether (1) MMN is altered in cirrhotic patients with MHE, compared to those without MHE, (2) MMN changes in parallel with performance in attentio…

AdultMalemedicine.medical_specialtyPsychometricsPsychometricsMismatch negativityFlicker fusion thresholdAudiologybehavioral disciplines and activitiesmedicineHumansAttentionLongitudinal StudiesHepatic encephalopathyHepatologyReceiver operating characteristicbusiness.industryCognitionMiddle Agedmedicine.diseaseSchizophreniaCase-Control StudiesHepatic EncephalopathyStroop TestEvoked Potentials AuditoryFemalebusinesshuman activitiespsychological phenomena and processesStroop effect
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Altered postural control and stability in cirrhotic patients with minimal hepatic encephalopathy correlate with cognitive deficits

2017

Background & Aims: Cognitive dysfunction in cirrhotic patients with minimal hepatic encephalopathy (MHE) is associated with falls. Alterations in postural control and stability could contribute to increase falls risk in these patients. We aimed to assess whether postural control and direction-specific limits of stability are altered in cirrhotic patients with MHE compared to patients without MHE and controls. We also assessed if alterations in postural control correlate with neurological impairment and/or blood biomarkers. Methods: Posturography analysis, attention Stroop test and bimanual and visuo-motor coordination tests were performed in 18 controls, 19 patients with cirrhosis without M…

Liver CirrhosisMaleCirrhosisPsychometricslimits of stabilityminimal hepatic encephalopathypostural control03 medical and health sciencesCognition0302 clinical medicineAmmoniaPredictive Value of TestsRisk FactorsfallsOdds RatiomedicineHumansAttentionPhysical ExaminationPostural BalanceHepatic encephalopathyBalance (ability)Chi-Square DistributionHepatologyImpaired Balancebusiness.industryInterleukinsPosturographyCognitionMiddle Agedmedicine.diseaseMotor coordinationLogistic ModelsCase-Control StudiesHepatic EncephalopathyAnesthesiaMultivariate AnalysisSensation DisordersStroop TestAccidental FallsFemale030211 gastroenterology & hepatologyCognition Disordersbusinesshuman activitiesPsychomotor Performance030217 neurology & neurosurgeryStroop effect
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