0000000000283046

AUTHOR

Guido De Guidi

showing 3 related works from this author

Swellable microparticles containing Suprofen: evaluation of in vitro release and photochemical behaviour

1998

Suprofen, an anti-inflammatory drug was incorporated in polymer networks based on biocompatible macromolecules, such as alpha,beta-polyasparthydrazide (PAHy) and alpha,beta-poly(N-hydroxyethyl)-DL-aspartamide (PHEA) crosslinked by glutaraldehyde or gamma-rays, respectively. Swelling tests carried out in aqueous media showed that pH value affects the swelling degree of the prepared hydrogels. In vitro release tests were performed in simulated gastrointestinal fluids (pH 1/6.8) using the pH variation method and in phosphate-buffered saline, pH 7.4. Experimental data indicated that Suprofen was released in a sustained way both from PAHy and PHEA microparticles. Further, incorporation of Suprof…

ErythrocytesPlasma SubstitutesSuprofenPharmaceutical ScienceSuprofenHemolysisDosage formchemistry.chemical_compoundmedicineHumansOrganic chemistryParticle SizeActive ingredientGastric JuicePhotosensitizing AgentsChromatographyAnti-Inflammatory Agents Non-SteroidalHydrogen-Ion ConcentrationNylonsCross-Linking ReagentsHydrazineschemistryGlutaralDelayed-Action PreparationsSelf-healing hydrogelsLiberationGlutaraldehydeSwellingmedicine.symptomPeptidesDrug carrierGelsmedicine.drugJournal of Controlled Release
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New hydrogel matrices containing an anti-inflammatory agent. Evaluation of in vitro release and photoprotective activity.

2002

In the present work. the preparation and characterization of hydrogels based on alpha,beta-polyaspartylhydrazide (PAHy) chemically crosslinked with ethyleneglycol diglycidylether (EGDGE) containing Tolmetin sodium salt, are reported. In particular, these samples have been prepared both as water swellable microparticles and as gels at two different crosslinking degrees. The incorporation of Tolmetin sodium salt in PAHy-EGDGE microparticles has been performed after the crosslinking reaction by a soaking procedure or during the formation of the network. The influence of drug loading procedure on Tolmetin release has been evaluated by performing in vitro release study in simulated gastrointesti…

medicine.drug_classPhotochemistrySodiumBiophysicsSynthetic membranechemistry.chemical_elementSalt (chemistry)BioengineeringIn Vitro TechniquesCrystallography X-RayAnti-inflammatoryHydrogel Polyethylene Glycol DimethacrylateBiomaterialsmedicineOrganic chemistryTolmetinchemistry.chemical_classificationChromatographyAnti-Inflammatory Agents Non-Steroidalmedicine.diseaseIn vitroHemolysischemistryMechanics of MaterialsSelf-healing hydrogelsCeramics and CompositesTolmetinmedicine.drugBiomaterials
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Effect of?-cyclodextrin complexation on the photohaemolitic activity induced by Ketoprofen and Naproxen sensitization

1993

Red blood cell lysis photosensitized by two non-steroidal anti-inflammatory drugs Naproxen (NAP) and Ketoprofen (KPF) was investigated in the presence of β-cyclodextrin (β-Cyd). The photohaemolysis was inhibited by the addition of β-Cyd both for NAP and, to a lesser extent, for KPF. The protective action was found only in a restricted range of concentration of β-Cyd. Higher amounts of β-Cyd interfered with the resistance of the cell to the osmotic shock induced by the photosensitization process. The complexing action of β-Cyd was ascertained through UV-vis absorption spectroscopy, induced circular dichroism and emission spectroscopy. The isolated complexes Naproxen-β-Cyd (NAP-β-Cyd) and Ket…

chemistry.chemical_classificationKetoprofenNaproxenCircular dichroismLysisCyclodextrinOsmotic shockStereochemistryGeneral ChemistryCondensed Matter PhysicsNapchemistryBiophysicsmedicinePhototoxicityFood Sciencemedicine.drugJournal of Inclusion Phenomena and Molecular Recognition in Chemistry
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