6533b7d6fe1ef96bd1266805
RESEARCH PRODUCT
Swellable microparticles containing Suprofen: evaluation of in vitro release and photochemical behaviour
Giovanna PitarresiGaetano GiammonaSalvatore GiuffridaVincenzo TomarchioGuido De Guidisubject
ErythrocytesPlasma SubstitutesSuprofenPharmaceutical ScienceSuprofenHemolysisDosage formchemistry.chemical_compoundmedicineHumansOrganic chemistryParticle SizeActive ingredientGastric JuicePhotosensitizing AgentsChromatographyAnti-Inflammatory Agents Non-SteroidalHydrogen-Ion ConcentrationNylonsCross-Linking ReagentsHydrazineschemistryGlutaralDelayed-Action PreparationsSelf-healing hydrogelsLiberationGlutaraldehydeSwellingmedicine.symptomPeptidesDrug carrierGelsmedicine.drugdescription
Suprofen, an anti-inflammatory drug was incorporated in polymer networks based on biocompatible macromolecules, such as alpha,beta-polyasparthydrazide (PAHy) and alpha,beta-poly(N-hydroxyethyl)-DL-aspartamide (PHEA) crosslinked by glutaraldehyde or gamma-rays, respectively. Swelling tests carried out in aqueous media showed that pH value affects the swelling degree of the prepared hydrogels. In vitro release tests were performed in simulated gastrointestinal fluids (pH 1/6.8) using the pH variation method and in phosphate-buffered saline, pH 7.4. Experimental data indicated that Suprofen was released in a sustained way both from PAHy and PHEA microparticles. Further, incorporation of Suprofen in PAHy and PHEA networks provided a significant reduction of the drug photosensitizing activity, as evidenced by in vitro hemolysis tests.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1998-08-01 | Journal of Controlled Release |