0000000000284246
AUTHOR
Jean-françois Manceau
PADDIAG: Plasmon-Acoustic Device for in vitro Diagnosis
The aim of the project is to develop a plasmon-acoustic device for the real time detection of biomolecular interactions, in the prospect of cancer markers detection in blood samples from patients. In the context of early diagnosis, the detection of infinitesimal quantities of biomarkers is possible thanks to the breakdown of the equilibrium state of biochemical reactions. This could be obtained by the activation of the biological media using a system composed of a microdevice for generating acoustic waves coupled with a fluidic network. The latter system will be integrated on a detection device based on surface plasmon resonance. Here, we present design, realization and characterization of …
Design and fabrication of an acoustic micromixer for biological media activation
International audience; The bioassay of infinitesimal quantities of protein markers in biological samples is the way to early cancer detection. However, this detection can be limited by the diffusion of these macromolecules (analytes) from the bulk to the sensor chip (surface of ligands). Here, we propose a new method to overcome this drawback by the activation of the biological media during the detection step. The principle consists in using ultrasonic vibrations in order to disrupt the equilibrium states of such biomolecular reactions and performing simultaneous detection inside an acoustic micromixer. Technological realization and initial characterizations of the device have been perform…