0000000000284247
AUTHOR
Reda Yahiaoui
PADDIAG: Plasmon-Acoustic Device for in vitro Diagnosis
The aim of the project is to develop a plasmon-acoustic device for the real time detection of biomolecular interactions, in the prospect of cancer markers detection in blood samples from patients. In the context of early diagnosis, the detection of infinitesimal quantities of biomarkers is possible thanks to the breakdown of the equilibrium state of biochemical reactions. This could be obtained by the activation of the biological media using a system composed of a microdevice for generating acoustic waves coupled with a fluidic network. The latter system will be integrated on a detection device based on surface plasmon resonance. Here, we present design, realization and characterization of …
Design and fabrication of an acoustic micromixer for biological media activation
International audience; The bioassay of infinitesimal quantities of protein markers in biological samples is the way to early cancer detection. However, this detection can be limited by the diffusion of these macromolecules (analytes) from the bulk to the sensor chip (surface of ligands). Here, we propose a new method to overcome this drawback by the activation of the biological media during the detection step. The principle consists in using ultrasonic vibrations in order to disrupt the equilibrium states of such biomolecular reactions and performing simultaneous detection inside an acoustic micromixer. Technological realization and initial characterizations of the device have been perform…
Electrogeneration of Diiodoaurate in Dimethylsulfoxide on Gold Substrate and Localized Patterning
International audience; A localized etching of gold surface by scanning electrochemical microscope technique is presented where a dimethylsulfoxide-based electrolyte charged with iodine is used. The electrogenerated triiodide ion at the platinum ultramicroelectrode tip (feedback mode) acts as an oxidant for gold surface. The effects of electrode diameter and the bias time have been investigated. The approach curve method was used to hold the electrode tip close to the gold surface. A scanning electron microscope is used to observe the etched gold surfaces where disk-shaped dots are generated. The diameter of these holes depends directly on the Pt electrode diameter and the bias time.
Mathematical model for the adsorption-induced nonlocal frequency shift in adatoms-nanobeam system
Abstract This paper models and investigates the resonance frequency shift induced by the adsorption phenomena for an adatoms-nanobeam system including the small scale effect as well as rotary inertia and shear distortion effects. The Lennard-Jones (6–12) type potential is used to determine the adsorption-induced energy owing van der Waals (vdW) interaction mechanism between adatom-adatom and adatom-substrate. The small scale effect is introduced by using Eringen's nonlocal elasticity theory while the explicit expressions of inertia moment and shear force are derived from the standard Timoshenko beam equations in which the residual stress effect is accounted as an additive axial load. Numeri…