0000000000285560
AUTHOR
Junhee Lee
Measurements of Tumor Blood Flow Using Intraperitoneal Deuterium and 2H-NMR Spectroscopy
Tumors usually have a sparse, disorganized, and inefficient vascular network that leaves a large fraction of the tumor cells in an oxygen deprived and hostile metabolic microenvironment. Hence tumor blood flow, or more correctly nutritive perfusion, has important interactions with treatment efficacy. For example, hypoxic tumor cells, which occur in tumors with low blood flow, are less susceptible to radiation and are probably responsible for most radiation treatment failures (Adams, 1981). Similarly, cytotoxic drug delivery could be predicted by blood flow measurements, with clear implications regarding the expected success of chemotherapy. Thus, the ability to conveniently measure tumor bl…
Measurement of Human Tumor Blood Flow: A Positron Technique Using an Artifact of High Energy Radiation Therapy
For at least three decades (1–6) there has been an interest in measuring tumor blood flow (TBF) and in the determination of its relation to the response of human tumors to radiation, drug therapies, and to the probability of development of distant metastases. The proton activation method which will be described below allows daily measurements of blood flow, in only 7 minutes, in patients being irradiated by photons of ≥20 MV, or by protons and other heavy particles.