Effects of the static magnetic field generated by a 0.5 MRI unit on intracellular calcium concentration and IFN- g release of human CD4 T cells

Effects of the static magnetic field generated by 0.5 T MRI unit on human CD4+ T cells activation patterns.

EFFECTS OF THE STATIC MAGNETIC FIELD GENERATED BY 0.5 T MRI UNIT ON INTRACELLULAR CALCIUM CONCENTRATION AND TNF-ALPHA RELEASE OF HUMAN MACROPHAGES

EFFECTS OF THE STATIC MAGNETIC FIELD GENERATED BY 0.5 T MRI UNIT ON INTRACELLULAR CALCIUM CONCENTRATION AND IFN-GAMMA RELEASE OF HUMAN CD4+ T CELLS.

Effetti biologici del campo magnetico statico da 0,5 T generato da un tomografo RM sul rilascio di citochine da linfociti e macrofagi

In vivo manipulation of Vgamma9Vdelta2 T cells with zoledronate and low-dose interleukin-2 for immunotherapy of advanced breast cancer patients.

The potent anti-tumour activities of gamma delta T cells have prompted the development of protocols in which gamma delta-agonists are administered to cancer patients. Encouraging results from small Phase I trials have fuelled efforts to characterize more clearly the application of this approach to unmet clinical needs such as metastatic carcinoma. To examine this approach in breast cancer, a Phase I trial was conducted in which zoledronate, a V gamma 9V delta 2 T cell agonist, plus low-dose interleukin (IL)-2 were administered to 10 therapeutically terminal, advanced metastatic breast cancer patients. Treatment was well tolerated and promoted the effector maturation of V gamma 9V delta 2 T …

Distinctive features of tumor-infiltrating γδ T lymphocytes in human colorectal cancer.

γδ T cells usually infiltrate many different types of cancer, but it is unclear whether they inhibit or promote tumor progression. Moreover, properties of tumor-infiltrating γδ T cells and those in the corresponding normal tissue remain largely unknown. Here we have studied features of γδ T cells in colorectal cancer, normal colon tissue and peripheral blood, and correlated their levels with clinicopathologic hallmarks. Flow cytometry and transcriptome analyses showed that the tumor comprised a highly variable rate of TILs (5–90%) and 4% γδ T cells on average, with the majority expressing Vδ1. Most Vδ1 and Vδ2 T cells showed a predominant effector memory phenotype and had reduced production…