6533b839fe1ef96bd12a5d4b
RESEARCH PRODUCT
Distinctive features of tumor-infiltrating γδ T lymphocytes in human colorectal cancer.
Marie TosoliniMatilde TodaroSerena MeravigliaGiorgio StassiSalvatore VieniFrancesco DieliVeronica CatalanoC. La MendolaE. Lo PrestiGiuseppe CiceroValentina OrlandoJean-jacques Fourniésubject
0301 basic medicinelcsh:Immunologic diseases. Allergycolon cancer; DFS; IFN-g; TILs; gd T cells; Immunology and Allergy; Immunology; OncologyColorectal cancerImmunologyBiologyifn-γDFStilslcsh:RC254-28203 medical and health sciencesIFN-gmedicineCytotoxic T cellImmunology and AllergyOriginal ResearchSettore MED/04 - Patologia Generaleγδ t cellsCancergd T cellTILmedicine.diseaselcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens030104 developmental biologycolon cancerOncologyTumor progressionImmunologylcsh:RC581-607description
γδ T cells usually infiltrate many different types of cancer, but it is unclear whether they inhibit or promote tumor progression. Moreover, properties of tumor-infiltrating γδ T cells and those in the corresponding normal tissue remain largely unknown. Here we have studied features of γδ T cells in colorectal cancer, normal colon tissue and peripheral blood, and correlated their levels with clinicopathologic hallmarks. Flow cytometry and transcriptome analyses showed that the tumor comprised a highly variable rate of TILs (5–90%) and 4% γδ T cells on average, with the majority expressing Vδ1. Most Vδ1 and Vδ2 T cells showed a predominant effector memory phenotype and had reduced production of IFN- γ which was likely due to yet unidentified inhibitory molecules present in cancer stem cell secretome. Transcriptome analyses revealed that patients containing abundant γδ T cells had significantly longer 5-year disease free survival rate, suggesting their efficacy in controlling tumor at very early stage.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2017-01-01 | Oncoimmunology |