0000000000299389

AUTHOR

Julian Künzel

showing 3 related works from this author

Randomized controlled single‐blinded clinical trial of functional voice outcome after vascular targeting KTP laser microsurgery of early laryngeal ca…

2019

Abstract Background Local control rate (LCR) of early glottic cancer is high after radiation therapy or transoral laser microsurgery (TLM). The aim of this study was to investigate functional voice outcome after TLM using a microvessel‐ablative potassium‐titanyl‐phosphate (KTP) laser in comparison with a gold standard cutting CO2 laser. Methods The primary end point of this prospective, randomized, single‐blinded, clinical phase II study with control group was voice outcome during a follow‐up of 6 months assayed by Voice Handicap Index (VHI‐30)‐questionnaires in patients with unilateral high‐grade dysplasia, carcinoma in situ or early glottic cancer undergoing TLM‐KTP (n = 8) or TLM‐CO2 (n …

MaleMicrosurgeryTime Factorsmedicine.medical_treatmentLasers Solid-State0302 clinical medicineClinical endpointSingle-Blind MethodProspective StudiesTransoral laser microsurgery030223 otorhinolaryngologyEarly Detection of CancerAged 80 and overMiddle AgedTreatment Outcome030220 oncology & carcinogenesisCarcinoma Squamous CellOriginal ArticleFemaleLaser Therapymedicine.medical_specialtyCO2 laserVoice QualityT1 glottic cancerVoice Handicap Index (VHI‐30)Statistics Nonparametric03 medical and health scienceslocal control ratemedicineHumansNeoplasm InvasivenessVoice Handicap IndexLaryngeal NeoplasmsAgedNeoplasm Stagingbusiness.industryCarcinoma in situReproducibility of ResultsCancerOriginal ArticlesRecovery of Functionmedicine.diseaseSurgeryClinical trialRadiation therapyangiolytic therapyOtorhinolaryngologyDysplasiaLasers GasbusinessFollow-Up StudiesHead & Neck
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Head and Neck Paragangliomas

2016

Head and neck paragangliomas are highly vascularized neuroendocrine tumors derived from the extra-adrenal paraganglia of the autonomic nervous system. These tumors may occur either sporadically or in the context of a hereditary familial tumor syndrome, and multifocal presentations are observed, particularly in hereditary cases. Hereditary paragangliomas are mostly caused by mutations in the succinate dehydrogenase complex genes. Early imaging, with ultrasonography of the neck and magnetic resonance imaging (MRI) of the skull base, is essential for localizing and assessing the extent of the tumor, as well as for precise planning of the treatment approach. Views regarding the treatment of cho…

medicine.medical_specialtyModalitiesmedicine.diagnostic_testbusiness.industrymedicine.medical_treatmentCranial nervesMagnetic resonance imagingContext (language use)Neuroendocrine tumorsmedicine.diseaseComorbidityRadiation therapySkullmedicine.anatomical_structuremedicineRadiologybusiness
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Evaluation der Ösophagoskopie im Staging und Restaging von Kopf-Hals-Plattenepithelkarzinomen

2020

Zusammenfassung Hintergrund Die Ösophagoskopie als Teil der Panendoskopie ist ein wichtiger Bestandteil der Diagnostik und Nachsorge von Patienten mit Kopf-Hals-Plattenepithelkarzinomen (HNSCC). Zweitkarzinome haben gravierenden Einfluss auf die Therapie der Primärerkrankung. Diese Arbeit soll prüfen, ob die routinemäßige Ösophagoskopie gerechtfertigt ist oder ob prädiktive Faktoren eine Selektion von Patienten mit erhöhtem Risikoprofil erlauben. Material und Methoden In einem systematischen Review wurden die Inzidenz von Zweitkarzinomen des Ösophagus und die Komplikationsrate der Ösophagoskopie erfasst. Eine retrospektive Auswertung erfolgte am eigenen Patientenkollektiv. Zur Evaluation de…

Gynecology03 medical and health sciencesmedicine.medical_specialty0302 clinical medicineOtorhinolaryngologybusiness.industry030220 oncology & carcinogenesismedicine030211 gastroenterology & hepatologymedicine.diseasebusinessHead and neck squamous-cell carcinomaLaryngo-Rhino-Otologie
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