Randomized controlled single‐blinded clinical trial of functional voice outcome after vascular targeting KTP laser microsurgery of early laryngeal cancer

Abstract Background Local control rate (LCR) of early glottic cancer is high after radiation therapy or transoral laser microsurgery (TLM). The aim of this study was to investigate functional voice outcome after TLM using a microvessel‐ablative potassium‐titanyl‐phosphate (KTP) laser in comparison with a gold standard cutting CO2 laser. Methods The primary end point of this prospective, randomized, single‐blinded, clinical phase II study with control group was voice outcome during a follow‐up of 6 months assayed by Voice Handicap Index (VHI‐30)‐questionnaires in patients with unilateral high‐grade dysplasia, carcinoma in situ or early glottic cancer undergoing TLM‐KTP (n = 8) or TLM‐CO2 (n …

Time‐dependent induction of vascular oxidative stress, inflammation, endothelial dysfunction and high blood pressure by aircraft noise exposure in mice

The role of structured surgical planning in the learning process of functional endoscopic sinus surgery

Die Rolle der strukturierten Operationsplanung im Lernprozess der funktionell endoskopischen Nasennebenhöhlenchirurgie

Die Vibrant Soundbridge®: Ein alternatives Hörsystem bei Vorschulkindern mit Gehörgangsatresie

Hintergrund: Die Versorgung von Kindern mit Gehorgangsatresie stellt einen hohen Anspruch an Mediziner und Akustiker. Herkommliche Horsysteme werden oft nicht toleriert, womit sie die Forderung nach einer fruhzeitigen und effizienten Versorgung der Horstorung nicht erfullen. Ziel der vorliegenden Studie ist daher die Untersuchung der Versorgungsqualitat von Kindern vor dem 6. Lebensjahr mit dem Mittelohrimplantat VSB® bei uni- bzw. bilateraler Gehorgangsatresie. Material und Methoden: Bei 16 Kindern, 13 mit uni-, 3 mit bilateraler Gehorgangsatresie, implantiert mit einer Vibrant Soundbridge (VSB®) im Alter von durchschnittlich 2;11±1;6 Jahren, wurde 3 Monate nach Erstanpassung des Audioproz…

Aircraft noise exposure drives the activation of white blood cells and induces microvascular dysfunction in mice

Epidemiological studies showed that traffic noise has a dose-dependent association with increased cardiovascular morbidity and mortality. Whether microvascular dysfunction contributes significantly to the cardiovascular health effects by noise exposure remains to be established. The connection of inflammation and immune cell interaction with microvascular damage and functional impairment is also not well characterized. Male C57BL/6J mice or gp91phox−/y mice with genetic deletion of the phagocytic NADPH oxidase catalytic subunit (gp91phox or NOX-2) were used at the age of 8 weeks, randomly instrumented with dorsal skinfold chambers and exposed or not exposed to aircraft noise for 4 days. Pro…

Kostenvergleichsanalyse von flexiblen HNO-Endoskopen

Zusammenfassung Hintergrund Die hygienische, richtliniengetreue Wiederaufbereitung von komplexen Instrumenten wie flexiblen HNO-Endoskopen mit und ohne Arbeitskanal stellt Kliniken und Praxen zunehmend vor große Herausforderungen. Ziel der vorliegenden Studie war es daher, die Kosten für ein wiederaufbereitbares Endoskopie-System mit 2 Einweg-Endoskopie-Systemen zu vergleichen und daraus mögliche strategische Überlegungen abzuleiten. Methodik Hierzu wurde eine Kostenvergleichsanalyse bzw. Kostenminimierungsanalyse des an der Hals-, Nasen-, Ohrenklinik und Poliklinik der Universitätsmedizin Mainz vorgehaltenen Endoskopie-Systems mit 2 Einweg-Endoskopie-Systemen der Firma Ambu und Karl Storz …

In vivo analysis of noise dependent activation of white blood cells and microvascular dysfunction in mice

This article contains supporting information on data collection for the research article entitled “Aircraft noise exposure drives the activation of white blood cells and induces microvascular dysfunction in mice” by Eckrich et al. We found that noise-induced stress triggered microvascular dysfunction via involvement of innate immune-derived reactive oxygen species. In this article, we present the instrumentation of mice with dorsal skinfold chambers for in vivo microscopic imaging of blood flow, interaction of leukocytes with the vascular wall (also by fluorescent labelling of blood cells) and vessel diameter. In addition, we explain the preparation of cerebral arterioles for measurement of…

Early Alterations of Endothelial Nitric Oxide Synthase Expression Patterns in the Guinea Pig Cochlea After Noise Exposure.

Constitutively expressed endothelial nitric oxide synthase (eNOS) is supposed to play a role in noise-induced nitric oxide (NO)-production. It is commonly known that intense noise exposure results in inducible NOS (iNOS) expression and increased NO-production, but knowledge about a contribution of the eNOS isoform is still lacking. Effects of noise exposure on eNOS immunolabeling were determined in male guinea pigs ( n=24). For light microscopic analysis, 11 animals were exposed to 90 dB for 1 hr and 6 animals were used as controls. After exposure, eNOS immunostaining was performed on paraffin sections, and the staining intensities were quantified for 4 cochlear regions. For electron micro…