0000000000303129

AUTHOR

Tugce Pehlivan

showing 4 related works from this author

Embryo Aneuploidy Screening for Unexplained Recurrent Miscarriage: A Minireview

2005

Problem:  The aim of this study was to investigate the incidence of chromosomal abnormalities in unexplained recurrent miscarriage (RM) patients and assess the role of pre-implantation genetic diagnosis (PGD) in preventing subsequent pregnancy loss and improving pregnancy outcome. Method of Study:  Pre-implantation genetic diagnosis was performed in 241 RM cycles and in 35 cycles in patients undergoing PGD for sex-linked diseases (control group). Chromosomes 13, 16, 18, 21, 22, X and Y were analysed by fluorescence in situ hybridization. Results:  The implantation and pregnancy rates in RM patients were 26.4 and 36.5% versus 20.6 and 29.0% in the control group, respectively. The percentage …

Gynecologymedicine.medical_specialtyPregnancyIn vitro fertilisationmedicine.diagnostic_testObstetricsmedicine.medical_treatmentIncidence (epidemiology)ImmunologyObstetrics and GynecologyAneuploidyBiologyAbortionmedicine.diseasemedicine.anatomical_structureReproductive MedicineRecurrent miscarriagemedicineImmunology and AllergyBlastocystFluorescence in situ hybridizationAmerican Journal of Reproductive Immunology
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Preimplantation genetic diagnosis by fluorescence in situ hybridization: clinical possibilities and pitfalls.

2003

Preimplantation genetic diagnosis using the fluorescence in situ hybridization technique (FISH) is being used widely to prevent the transmission of sex-linked diseases, to screen for translocations, and for aneuploidy screenng in specific invitro fertilization (IVF) patient groups, along with FISH analysis of spematozoa in intertile men. In this study, we aim to critically analyze our clinical results in patients at risk of transmitting sex-linked diseases (n = 55), in carriers of translocations (n = 43), in women who have recurent miscarriage (two or more miscarriages) (n = 128), recurrent IVF failure (three or more failed IVF attempts) (n = 47), and patients of advanced maternal age (37 y…

Adultmedicine.medical_specialtyGenetic LinkagePregnancy High-RiskAneuploidyFertilization in VitroBiologyPreimplantation genetic diagnosisTranslocation GeneticMiscarriageRecurrent miscarriagemedicineHumansAdvanced maternal ageTreatment FailureIn Situ Hybridization FluorescencePreimplantation DiagnosisGynecologyPregnancySex Chromosomesmedicine.diagnostic_testIncidence (epidemiology)Genetic Diseases InbornObstetrics and Gynecologymedicine.diseaseAbortion SpontaneousFemaleFluorescence in situ hybridizationMaternal AgeJournal of the Society for Gynecologic Investigation
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Impact of chromosomal abnormalities on preimplantation embryo development.

2007

Objectives To evaluate the influence of numerical chromosomal abnormalities on preimplantation embryo development. Methods This study includes 6936 embryos from 1245 women undergoing preimplantation genetic diagnosis (PGD). Indications for aneuploidy screening were: recurrent miscarriages, implantation failure, severe male factor, advanced maternal age, and mixed causes. Embryo biopsy was performed on day 3, and embryos were co-cultured until day 5, when embryo transfer was performed. Results In the aneuploidy screening regimen, normal euploid embryos showed significantly higher blastocyst rates (68.2%) compared to chromosomally abnormal (42.8%, p < 0.0001) and mosaic (53.7%, p < 0.0001) em…

Adultmedicine.medical_specialtyMonosomyanimal structuresAneuploidyEmbryonic DevelopmentTrisomyFertilization in VitroBiologyPreimplantation genetic diagnosisPregnancyCulture TechniquesmedicineHumansBlastocystAdvanced maternal ageEmbryo ImplantationGenetic TestingGenetics (clinical)In Situ Hybridization FluorescencePreimplantation DiagnosisGynecologyChromosomes Human XMosaicismObstetrics and GynecologyEmbryomedicine.diseaseAneuploidyEmbryo transfermedicine.anatomical_structureBlastocystembryonic structuresFemaleTrisomyMaternal AgePrenatal diagnosis
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Impact of preimplantation genetic diagnosis on IVF outcome in implantation failure patients

2003

Implantation failure (IF) is defined as three or more failed IVF attempts, and preimplantation genetic diagnosis (PGD) is being used in these patients to improve IVF outcome. PGD was performed in 49 implantation failure patients with a mean number of 4.2 +/- 1.6 previous IVF failures, and in nine fertile controls. Fluorescence in-situ hybridization (FISH) on blastomeres from biopsied day 3 embryos was performed for chromosomes 13, 16, 18, 21, 22, X and Y. There was a significantly higher rate of chromosomal abnormalities (67.4%) compared with controls (36.3%). In 57 cycles, a pregnancy rate of 34.0% and an implantation rate of 19.8% was observed in implantation failure patients compared wit…

Adultmedicine.medical_specialtyBiopsyPregnancy High-RiskAneuploidyFertilization in VitroPreimplantation genetic diagnosisPregnancyBiopsyHumansMedicineEmbryo ImplantationBlastocystIn Situ Hybridization FluorescencePreimplantation Diagnosisreproductive and urinary physiologyChromosome AberrationsGynecologyPregnancymedicine.diagnostic_testbusiness.industryObstetricsBlastocyst TransferObstetrics and GynecologyAneuploidyEmbryo Transfermedicine.diseaseCoculture TechniquesEmbryo transferPregnancy rateTreatment Outcomemedicine.anatomical_structureReproductive Medicineembryonic structuresFemalebusinessMaternal AgeDevelopmental BiologyReproductive BioMedicine Online
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