6533b7d7fe1ef96bd1268d09

RESEARCH PRODUCT

Embryo Aneuploidy Screening for Unexplained Recurrent Miscarriage: A Minireview

Carlos SimónJosé RemohíAntonio PellicerTugce PehlivanCarmen RubioLorena Rodrigo

subject

Gynecologymedicine.medical_specialtyPregnancyIn vitro fertilisationmedicine.diagnostic_testObstetricsmedicine.medical_treatmentIncidence (epidemiology)ImmunologyObstetrics and GynecologyAneuploidyBiologyAbortionmedicine.diseasemedicine.anatomical_structureReproductive MedicineRecurrent miscarriagemedicineImmunology and AllergyBlastocystFluorescence in situ hybridization

description

Problem:  The aim of this study was to investigate the incidence of chromosomal abnormalities in unexplained recurrent miscarriage (RM) patients and assess the role of pre-implantation genetic diagnosis (PGD) in preventing subsequent pregnancy loss and improving pregnancy outcome. Method of Study:  Pre-implantation genetic diagnosis was performed in 241 RM cycles and in 35 cycles in patients undergoing PGD for sex-linked diseases (control group). Chromosomes 13, 16, 18, 21, 22, X and Y were analysed by fluorescence in situ hybridization. Results:  The implantation and pregnancy rates in RM patients were 26.4 and 36.5% versus 20.6 and 29.0% in the control group, respectively. The percentage of abnormal embryos was significantly increased in RM patients compared with controls. Conclusions:  Recurrent miscarriage is associated with a higher incidence of chromosomally abnormal embryos. In vitro fertilization (IVF) plus PGD is an important step in the management of these couples.

yearjournalcountryeditionlanguage
2005-03-10American Journal of Reproductive Immunology
https://doi.org/10.1111/j.1600-0897.2005.00260.x