Intestinal Scavenger Receptors Are Involved in Vitamin K 1 Absorption

International audience; Vitamin K-1 (phylloquinone) intestinal absorption is thought to be mediated by a carrier protein that still remains to be identified. Apical transport of vitamin K-1 was examined using Caco-2 TC-7 cell monolayers as a model of human intestinal epithelium and in transfected HEK cells. Phylloquinone uptake was then measured ex vivo using mouse intestinal explants. Finally, vitamin K-1 absorption was compared between wild-type mice and mice overexpressing scavenger receptor class B type I (SR-BI) in the intestine and mice deficient in cluster determinant 36 (CD36). Phylloquinone uptake by Caco-2 cells was saturable and was significantly impaired by co-incubation with al…

Impact of nutraceuticals on markers of systemic inflammation: Potential relevance to cardiovascular diseases - A position paper from the International Lipid Expert Panel (ILEP).

Inflammation is a marker of arterial disease stemming from cholesterol-dependent to -independent molecular mechanisms. In recent years, the role of inflammation in atherogenesis has been underpinned by pharmacological approaches targeting systemic inflammation that have led to a significant reduction in cardiovascular disease (CVD) risk. Although the use of nutraceuticals to prevent CVD has largely focused on lipid-lowering (e.g, red-yeast rice and omega-3 fatty acids), there is growing interest and need, especially now in the time of coronavirus pandemic, in the use of nutraceuticals to reduce inflammatory markers, and potentially the inflammatory CVD burden, however, there is still not en…

Introduction. Vulnérabilités étudiantes: les chemins inattendus de la réussite

International audience

L’autonomisation des étudiants au risque des vulnérabilité

Les chemins inattendus de la réussite étudiante

International audience; Quelles sont les situations de vulnérabilité que les étudiant·es rencontrent ? Comment illustrer leur caractère réversible, qui emporte certain·es sur des chemins inattendus de la réussite ? Notre propos trouve un écho particulier...

La poursuite d'études après un master

Nutraceutical approaches to non-alcoholic fatty liver disease (NAFLD): A position paper from the International Lipid Expert Panel (ILEP)

Non-Alcoholic Fatty Liver Disease (NAFLD) is a common condition affecting around 10–25% of the general adult population, 15% of children, and even > 50% of individuals who have type 2 diabetes mellitus. It is a major cause of liver-related morbidity, and cardiovascular (CV) mortality is a common cause of death. In addition to being the initial step of irreversible alterations of the liver parenchyma causing cirrhosis, about 1/6 of those who develop NASH are at risk also developing CV disease (CVD). More recently the acronym MAFLD (Metabolic Associated Fatty Liver Disease) has been preferred by many European and US specialists, providing a clearer message on the metabolic etiology of the dis…

The social dimension of students in France, national and local perspectives

International audience; The quantitative democratisation of the access to higher education in France has led to a more diversified student population particularly within universities both in terms of academic profile and social background. The different tracks (i.e. academic and vocational) within upper secondary school prepare differently students for higher education, and can lead to different study conditions and experiences within higher education. Indeed, the students from the vocational tracks are less well prepared to adapt to the difficulties of student life. In our presentation we will focus on first : year students and the different dimensions of their student life (academic, soci…

L'alternance à l'Université, les Masters et leurs diplômés

International audience

Statin therapy in athletes and patients performing regular intense exercise - Position paper from the International Lipid Expert Panel (ILEP)

Abstract Acute and chronic physical exercises may enhance the development of statin-related myopathy. In this context, the recent (2019) guidelines of the European Society of Cardiology (ESC) and the European Atherosclerosis Society (EAS) for the management of dyslipidemias recommend that, although individuals with dyslipidemia should be advised to engage in regular moderate physical exercise (for at least 30 min daily), physicians should be alerted with regard to myopathy and creatine kinase (CK) elevation in statin-treated sport athletes. However it is worth emphasizing that abovementioned guidelines, previous and recent ESC/EAS consensus papers on adverse effects of statin therapy as wel…

Les vulnérabilités étudiantes : quels effets sur les parcours ?

Les vulnérabilités étudiantes sont cumulatives et multidimensionnelles. Elles ont un effet négatif sur les parcours d’études et la réussite au diplôme des étudiants concernés.