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RESEARCH PRODUCT
Statin therapy in athletes and patients performing regular intense exercise - Position paper from the International Lipid Expert Panel (ILEP)
Niki KatsikiDimitri P. MikhailidisGani BajraktariAndre R. MiserezArrigo F.g. CiceroEric BruckertMaria-corina SerbanErkin M. MirrakhimovFahad AlnouriŽEljko ReinerGyörgy ParaghAmirhossein SahebkarMaciej BanachFahad AlnouriFahma AmarAtanas G. AtanasovGani BajraktariMaciej BanachMarcin A. BartlomiejczykBojko BjelakovicEric BruckertAgata Bielecka-dabrowaAlberto CafferataRichard CeskaArrigo F.g. CiceroXavier ColletOlivier DescampsNair DevakiDragan DjuricRonen DurstMarat V. EzhovZlatko FrasDan GaitaStephan Von HaehlingAdrian V. HernandezSteven R. JonesJacek JozwiakNona KakauridzeNiki KatsikiAmit KheraKaram KostnerRaimondas KubiliusGustavs LatkovskisG.b. John ManciniA. David MaraisSeth S. MartinJulio Acosta MartinezMohsen MazidiDimitri P. MikhailidisErkin MirrakhimovAndre R. MiserezOlena MitchenkoPatrick MoriartySeyed Mohammad NabaviDemosthenes B. PanagiotakosGyörgy ParaghDaniel PellaPeter E. PensonZaneta PetrulionieneMatteo PirroArman PostadzhiyanRaman PuriAshraf RedaŽEljko ReinerJemaa RiadhDimitri RichterManfredi RizzoMassimiliano RuscicaAmirhossein SahebkarNaveed SattarMaria-corina SerbanAbdulla M.a. ShehabAleksandr B. ShekCesare R. SirtoriClaudia StefanuttiTomasz TomasikPeter P. TothMargus ViigimaaDragos VinereanuBranislav VohnoutMichal VrablikNathan D. WongHung-i YehJiang ZhishengAndreas Zirliksubject
0301 basic medicinemedicine.medical_specialtyConsensusSports medicineContext (language use)Physical exercise03 medical and health sciences0302 clinical medicineAthlethsMuscular DiseasesStatin intoleranceMedicineHumansAdverse effectAthlethExerciseMylagiaDyslipidemiasPharmacologybiologybusiness.industryAthletesExercisesAthleths Exercises Management Mylagia Statin intolerance.Athleths; Exercises; Management; Mylagia; Statin intolerancemedicine.diseasebiology.organism_classificationManagement030104 developmental biologyAthletes030220 oncology & carcinogenesisPhysical therapyPosition paperStatin therapyHydroxymethylglutaryl-CoA Reductase InhibitorsbusinessDyslipidemiadescription
Abstract Acute and chronic physical exercises may enhance the development of statin-related myopathy. In this context, the recent (2019) guidelines of the European Society of Cardiology (ESC) and the European Atherosclerosis Society (EAS) for the management of dyslipidemias recommend that, although individuals with dyslipidemia should be advised to engage in regular moderate physical exercise (for at least 30 min daily), physicians should be alerted with regard to myopathy and creatine kinase (CK) elevation in statin-treated sport athletes. However it is worth emphasizing that abovementioned guidelines, previous and recent ESC/EAS consensus papers on adverse effects of statin therapy as well as other previous attempts on this issue, including the ones from the International Lipid Expert Panel (ILEP), give only general recommendations on how to manage patients requiring statin therapy on regular exercises. Therefore, these guidelines in the form of the Position Paper are the first such an attempt to summary existing, often scarce knowledge, and to present this important issue in the form of step-by-step practical recommendations. It is critically important as we might observe more and more individuals on regular exercises/athletes requiring statin therapy due to their cardiovascular risk.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2020-01-01 |