0000000000323804

AUTHOR

Banu C. Tel

showing 3 related works from this author

Alterations in striatal neuropeptide mRNA produced by repeated administration of L-DOPA, ropinirole or bromocriptine correlate with dyskinesia induct…

2002

Chronic administration of L-DOPA to MPTP-treated common marmosets induces marked dyskinesia while repeated administration of equivalent antiparkisonian doses of ropinirole and bromocriptine produces only mild involuntary movements. The occurrence of dyskinesia has been associated with an altered balance between the direct and indirect striatal output pathways. Using in situ hybridisation histochemistry, we now compare the effects of these drug treatments on striatal preproenkephalin-A (PPE-A) and adenosine A(2a) receptor mRNA expression as markers of the indirect pathway and striatal preprotachykinin (PPT) mRNA and preproenkephalin-B (PPE-B, prodynorphin) mRNA expression as markers of the d…

MaleDyskinesia Drug-Inducedmedicine.medical_specialtyIndolesCaudate nucleusStriatumIndirect pathway of movementAntiparkinson AgentsLevodopachemistry.chemical_compoundDopamine Uptake InhibitorsParkinsonian DisordersTachykininsInternal medicineNeural PathwaysmedicineAnimalsheterocyclic compoundsRNA MessengerProtein PrecursorsBromocriptineGeneral NeuroscienceMPTPPutamenNeuropeptidesReceptors Purinergic P1CallithrixEnkephalinsMazindoldopamine agonists peptide mRNAs L-DOPA 1-methyl-4-phenyl-1236-tetrahydropyridine primates dyskinesiaBromocriptinenervous system diseasesNeostriatumRopiniroleEndocrinologynervous systemchemistryDyskinesiaSettore BIO/14 - FarmacologiaFemalemedicine.symptommedicine.drugNeuroscience
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Increased neuropeptide Y mRNA expression in striatum in Parkinson's disease.

2003

High levels of neuropeptide Y (NPY) are found in basal ganglia where it is co-localised with somatostatin (SOM) and nicotinamide adenine dinucleotide phosphate-diaphorase (NADPH/d) in a population of striatal GABA containing interneurones. Although alterations occur in the levels of various neuropeptides in basal ganglia in Parkinson’s disease (PD), it is not known whether NPY is affected. Using in situ hybridisation immunohistochemistry, we have examined the distribution of NPY mRNA in the caudate nucleus, putamen and nucleus accumbens of normal individuals and patients with PD. NPY mRNA was weakly expressed in the caudate nucleus, putamen and nucleus accumbens in normal individuals with a…

Malemedicine.medical_specialtyIn situ hybridisationPopulationCaudate nucleusNeuropeptideStriatumBiologyNucleus accumbensNucleus AccumbensStriatumCellular and Molecular NeuroscienceNeuropeptide Y (NPY)InterneuronsInternal medicinemental disordersBasal gangliamedicineHumansNeuropeptide YRNA MessengereducationMolecular BiologyAgededucation.field_of_studyPutamenPutamenParkinson DiseaseMiddle AgedNeuropeptide Y receptorhumanitiesCorpus StriatumEndocrinologynervous systemGene Expression RegulationParkinson’s diseaseSettore BIO/14 - FarmacologiaFemaleCaudate NucleusBrain research. Molecular brain research
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6-Hydroxydopamine lesioning differentially affects α-synuclein mRNA expression in the nucleus accumbens, striatum and substantia nigra of adult rats

2002

The effect of a unilateral 6-hydroxydopamine (6-OHDA) lesion and/or repeated administration of levodopa (L-DOPA) to normal and 6-OHDA-lesioned rats on alpha-synuclein mRNA expression was investigated by in situ hybridization histochemistry. A 6-OHDA lesion of the nigro-striatal pathway alone, confirmed by the loss of nigral tyrosine hydroxylase mRNA expression, markedly decreased alpha-synuclein mRNA in the lesioned substantia nigra (SN). In contrast, the levels of alpha-synuclein mRNA in the denervated striatum and nucleus accumbens were not altered. Chronic administration of L-DOPA to normal or 6-OHDA-lesioned rats had no effect on alpha-synuclein mRNA expression in the SN, striatum or nu…

Malemedicine.medical_specialtyTyrosine 3-MonooxygenaseDopamineanimal diseasesDopamine AgentsSynucleinsNerve Tissue ProteinsSubstantia nigraStriatumNucleus accumbensBiologyDrug Administration ScheduleNucleus Accumbenschemistry.chemical_compoundDopamineInternal medicineBasal gangliamedicineAnimalsTyrosine hydroxylase mRNARNA MessengerRats WistarOxidopamineNeuronsHydroxydopamineTyrosine hydroxylaseGeneral NeuroscienceParkinson Diseaseα-Synuclein mRNARatsnervous system diseasesNeostriatumSubstantia NigraEndocrinologynervous systemchemistrySympatholyticsalpha-SynucleinSettore BIO/14 - Farmacologia6-HydroxydopamineOxidopaminemedicine.drugNeuroscience Letters
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