0000000000326156

AUTHOR

Rosa F Ruiz De Apodaca

showing 4 related works from this author

Diabetes potentiates acetylcholine-induced relaxation in rabbit renal arteries.

2001

Abstract The response of rabbit renal arteries to acetylcholine and its endothelial modulation in diabetes were investigated. Acetylcholine induced concentration-related endothelium-dependent relaxation of renal arteries that was significantly more potent in diabetic rabbits than in control rabbits. Pretreatment with NG-nitro- l -arginine ( l -NOArg), indomethacin, or l -NOArg plus indomethacin induced partial inhibition of acetylcholine-induced relaxation. Inhibition induced by l -NOArg plus indomethacin was significantly higher in arteries from diabetic rabbits than in arteries from control rabbits. In renal arteries depolarised with KCl 30 mM and incubated with l -NOArg plus indomethacin…

MaleNitroprussidemedicine.medical_specialtyArginineEndotheliumVasodilator AgentsIndomethacinProstacyclinNitric OxideNitroarginineNitric oxideDiabetes Mellitus Experimentalchemistry.chemical_compoundRenal Arterymedicine.arteryInternal medicineMedicineAnimalsRenal arteryEnzyme InhibitorsPharmacologybusiness.industryAnti-Inflammatory Agents Non-SteroidalAcetylcholineVasodilationEndocrinologymedicine.anatomical_structurechemistrycardiovascular systemSodium nitroprussideEndothelium VascularRabbitsbusinessAcetylcholinemedicine.drugArteryEuropean journal of pharmacology
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Influence of experimental diabetes on regulatory mechanisms of vascular response of rabbit carotid artery to acetylcholine

2000

Summary The purpose of this study was to analyse the influence of experimental diabetes on vascular response of rabbit carotid artery to acetylcholine (Ach). We compared the Ach-induced relaxant response of isolated arterial segments obtained from both control and diabetic animals. To assess the influence of the endothelium, this cell layer was mechanically removed in some of the arterial segments (“rubbed arteries”) from each experimental group. Ach induced a concentration-related endothelium-mediated relaxation of carotid artery from control rabbits that was significantly higher with respect to that obtained in diabetic animals. Pre-treatment with NG-nitro-L-arginine (L-NA) induced a conc…

MaleGene isoformmedicine.medical_specialtyEndotheliumVasodilator AgentsIndomethacinProstacyclinGuanidinesNitroarginineGeneral Biochemistry Genetics and Molecular BiologyDiabetes Mellitus ExperimentalNitric oxidechemistry.chemical_compoundInternal medicineDiabetes mellitusAlloxanmedicineAnimalsEnzyme InhibitorsGeneral Pharmacology Toxicology and PharmaceuticsEndothelial dysfunctionbusiness.industryAnti-Inflammatory Agents Non-SteroidalGeneral Medicinemedicine.diseaseAcetylcholineCarotid ArteriesEndocrinologymedicine.anatomical_structurechemistryArachidonic acidEndothelium VascularRabbitsbusinessAcetylcholinemedicine.drugLife Sciences
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Experimental diabetes induces hyperreactivity of rabbit renal artery to 5-hydroxytryptamine.

2002

Abstract The influence of diabetes on the response of isolated rabbit renal arteries to 5-hydroxytryptamine (5-HT) was examined. 5-HT induced a concentration-related contraction that was higher in arteries from diabetic rabbits than in arteries from control rabbits. Endothelium removal did not significantly modify 5-HT contractions in arteries from control rabbits but enhanced the response to 5-HT in arteries from diabetic rabbits. Incubation with N G -nitro- l -arginine ( l -NA) enhanced contractions to 5-HT in arteries from control and diabetic rabbits. In arteries with endothelium, this l -NA enhancement was lower in diabetic rabbits than in control rabbits. In arteries without endotheli…

Malemedicine.medical_specialtySerotoninContraction (grammar)EndotheliumIndomethacinIn Vitro TechniquesNitroarginineDiabetes Mellitus Experimentalchemistry.chemical_compoundNitroarginineRenal ArteryInternal medicinemedicine.arteryAlloxanmedicineAnimalsRenal arteryEnzyme InhibitorsPharmacologyDose-Response Relationship Drugbusiness.industryProstanoidDrug Synergismmedicine.anatomical_structureEndocrinologychemistryVasoconstrictionCirculatory systemRabbitsmedicine.symptomNitric Oxide SynthasebusinessVasoconstrictionBlood vesselEuropean journal of pharmacology
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Diabetes-induced changes in endothelial mechanisms implicated in rabbit carotid arterial response to 5-hydroxytryptamine

2000

Abstract The influence of diabetes on endothelial mechanisms implicated in the response of isolated rabbit carotid arteries to 5-hydroxytryptamine (5- HT ) was studied. 5-HT induced a concentration–dependent contraction that was potentiated in arteries from diabetic rabbits with respect to that in arteries from control rabbits. Endothelium removal potentiated 5-HT contractions in arteries from both control and diabetic rabbits but increased the maximum effect only in arteries from diabetic rabbits. Incubation of arterial segments with N G -nitro- l -arginine ( l- NA) enhanced the contractile response to 5-HT. This l -NA enhancement was greater in arteries from diabetic rabbits than in arter…

MaleSerotoninmedicine.medical_specialtyContraction (grammar)ArginineEndotheliumIndomethacinIn Vitro TechniquesGuanidinesNitroarginineDiabetes Mellitus ExperimentalNitric oxidechemistry.chemical_compoundInternal medicineDiabetes mellitusmedicineAnimalsEnzyme InhibitorsPharmacologyLagomorphaDose-Response Relationship DrugbiologyVascular diseasebusiness.industryProstanoidmedicine.diseasebiology.organism_classificationCarotid Arteriesmedicine.anatomical_structureEndocrinologychemistryVasoconstrictionKetamineEndothelium VascularRabbitsNitric Oxide SynthasebusinessEuropean Journal of Pharmacology
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