0000000000337420
AUTHOR
Igors Susinskis
Method development for the determination of 1,1-dimethylhydrazine by the high-performance liquid chromatography-mass spectrometry technique.
Unsymmetrical dimethyl hydrazine is highly toxic, carcinogenic compound, widely used for organic synthesis and drug development. Therefore, due to its high reactivity, direct analysis is problematic. Current study proposes to use derivatization reaction to increase selectivity and sensitivity of high-performance liquid chromatography–mass spectrometry method. Different derivatization agents were tested and optimal reaction media was found. Derivatization was performed by using small amounts of reagents to lower the cost of analysis. The full validation of the method was performed and it can be used in a routine control in pharmaceutical analysis. Method sensitivity is 0.15 ppm, and lineari…
Application of Bioaugmentation to Improve Pharmaceutical Wastewater Treatment Efficiency
Ecological harm and human health risks caused by environmental pollution with active pharmaceutical ingredients (API) nowadays is recognised as issue of growing concern. Widespread presence of human and veterinary API in aquatic environment clearly indicates persistence and low removal efficiency of these compounds at conventional pharmaceutical and municipal wastewater treatment plants (WWTP). Bioaugmentation of activated sludge systems with specialized microorganisms could be a powerful and environmentally friendly tool to enhance the removal efficiency of recalcitrant API. Selection of inoculum strains, that have appropriate enzymatic pathways to metabolise complex molecules of API, belo…