6533b7d9fe1ef96bd126c29c
RESEARCH PRODUCT
Method development for the determination of 1,1-dimethylhydrazine by the high-performance liquid chromatography-mass spectrometry technique.
Peteris MekssIgors SusinskisJuris Hmelnickissubject
ChromatographyElectrospray ionization010401 analytical chemistryGeneral Medicine010402 general chemistryTandem mass spectrometryMass spectrometry01 natural sciencesHigh-performance liquid chromatographyAtomic and Molecular Physics and Optics0104 chemical scienceschemistry.chemical_compoundchemistryDimethylhydrazineReactivity (chemistry)Organic synthesisDerivatizationSpectroscopydescription
Unsymmetrical dimethyl hydrazine is highly toxic, carcinogenic compound, widely used for organic synthesis and drug development. Therefore, due to its high reactivity, direct analysis is problematic. Current study proposes to use derivatization reaction to increase selectivity and sensitivity of high-performance liquid chromatography–mass spectrometry method. Different derivatization agents were tested and optimal reaction media was found. Derivatization was performed by using small amounts of reagents to lower the cost of analysis. The full validation of the method was performed and it can be used in a routine control in pharmaceutical analysis. Method sensitivity is 0.15 ppm, and linearity range is 0.15–2.70 ppm.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2018-02-28 | European journal of mass spectrometry (Chichester, England) |