0000000000338644

AUTHOR

H. Krause

showing 6 related works from this author

Commissioning of the vacuum system of the KATRIN Main Spectrometer

2016

The KATRIN experiment will probe the neutrino mass by measuring the β-electron energy spectrum near the endpoint of tritium β-decay. An integral energy analysis will be performed by an electro-static spectrometer (``Main Spectrometer''), an ultra-high vacuum vessel with a length of 23.2 m, a volume of 1240 m[superscript 3], and a complex inner electrode system with about 120 000 individual parts. The strong magnetic field that guides the β-electrons is provided by super-conducting solenoids at both ends of the spectrometer. Its influence on turbo-molecular pumps and vacuum gauges had to be considered. A system consisting of 6 turbo-molecular pumps and 3 km of non-evaporable getter strips ha…

010302 applied physicsPhysicsLight nucleusPhysics - Instrumentation and DetectorsSpectrometerSpectrometersPhysics::Instrumentation and DetectorsVacuum-basedFOS: Physical sciencesInstrumentation and Detectors (physics.ins-det)01 natural sciencesEnergy analysisNuclear physics0103 physical sciencesEnergy spectrumGas systems and purificationNeutrino detectorsddc:620010306 general physicsInstrumentationMathematical PhysicsEngineering & allied operationsKATRINdetectors
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First operation of the KATRIN experiment with tritium

2020

AbstractThe determination of the neutrino mass is one of the major challenges in astroparticle physics today. Direct neutrino mass experiments, based solely on the kinematics of $$\upbeta $$β-decay, provide a largely model-independent probe to the neutrino mass scale. The Karlsruhe Tritium Neutrino (KATRIN) experiment is designed to directly measure the effective electron antineutrino mass with a sensitivity of $$0.2\hbox { eV}$$0.2eV ($$90\%$$90% CL). In this work we report on the first operation of KATRIN with tritium which took place in 2018. During this commissioning phase of the tritium circulation system, excellent agreement of the theoretical prediction with the recorded spectra was …

Physics - Instrumentation and DetectorsCosmology and Nongalactic Astrophysics (astro-ph.CO)Physics and Astronomy (miscellaneous)Physics::Instrumentation and DetectorsFOS: Physical scienceslcsh:Astrophysics[PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex]TritiumKATRIN01 natural sciencesantineutrino/e: massHigh Energy Physics - ExperimentNuclear physicsHigh Energy Physics - Experiment (hep-ex)lcsh:QB460-4660103 physical sciences[PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex]lcsh:Nuclear and particle physics. Atomic energy. RadioactivityMass scaleddc:530Electron Capture[PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det]Nuclear Experiment (nucl-ex)010306 general physicsEngineering (miscellaneous)Nuclear ExperimentAstroparticle physicsPhysics010308 nuclear & particles physicstritiumPhysicsQuímicaInstrumentation and Detectors (physics.ins-det)sensitivityddc:lcsh:QC770-798TritiumHigh Energy Physics::ExperimentNeutrinoPräzisionsexperimente - Abteilung BlaumNeutrino Mass[PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph]Electron neutrinoperformanceKATRINAstrophysics - Cosmology and Nongalactic Astrophysicsexperimental results
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SARS-CoV-2 vaccination modelling for safe surgery to save lives: data from an international prospective cohort study

2021

Abstract Background Preoperative SARS-CoV-2 vaccination could support safer elective surgery. Vaccine numbers are limited so this study aimed to inform their prioritization by modelling. Methods The primary outcome was the number needed to vaccinate (NNV) to prevent one COVID-19-related death in 1 year. NNVs were based on postoperative SARS-CoV-2 rates and mortality in an international cohort study (surgical patients), and community SARS-CoV-2 incidence and case fatality data (general population). NNV estimates were stratified by age (18–49, 50–69, 70 or more years) and type of surgery. Best- and worst-case scenarios were used to describe uncertainty. Results NNVs were more favourable in su…

MaleCOVID-19 Vaccinesafe surgery; vaccination modelling; COVID-19Vascular damage Radboud Institute for Health Sciences [Radboudumc 16]MULTICENTERComorbidity030230 surgery0302 clinical medicinephase 3 clinical trial (topic)Case fatality rateProspective StudiesSARS-CoV-2 Vaccination Safe surgeryCOVID-19/epidemiologySARS-CoV-2 ; vaccination ; safe surgeryeducation.field_of_studycase fatality rateVaccinationVaccinationAdolescent; Adult; Aged; COVID-19; COVID-19 Vaccines; Comorbidity; Elective Surgical Procedures; Female; Humans; Male; Middle Aged; Postoperative Complications; Preoperative Period; Prospective Studies; SARS-CoV-2; Vaccination; Young Adulthealth care policyElective Surgical Procedures030220 oncology & carcinogenesisvaccination modellingPreoperative PeriodCOVID-19; SARS-CoV-2; cancer; vaccination; outcome; mortality; infection; modellingCohort studyprospective studyHumanmedicine.medical_specialtyArticle03 medical and health sciencesSARS-CoV-2 vaccinationSDG 3 - Good Health and Well-beingCOVID-19 Vaccines/pharmacologyHumansVaccination/methodsElective surgeryeducationAgedScience & TechnologyElective Surgical Procedureadult; aged; Article; cancer grading; cancer surgery; case fatality rate; computer assisted tomography; elective surgery; female; follow up; health care policy; human; incidence; infection rate; infection risk; major clinical study; male; middle aged; mortality; outcome assessment; phase 3 clinical trial (topic); preoperative care; prospective study; sensitivity analysis; seroprevalence; Severe acute respiratory syndrome coronavirus 2; vaccination; young adult; COVID-19; COVID-19 Vaccines; Comorbidity; Elective Surgical Procedures; Postoperative Complications; Preoperative Period; SARS-CoV-2; Vaccination; surgery.Cura preoperatòriamajor clinical studymortalityinfectionProspective StudieincidenceSurgeryHuman medicinePostoperative Complication610 Medizin und GesundheitAcademicSubjects/MED00910Settore MED/18 - CHIRURGIA GENERALESettore MED/29 - CHIRURGIA MAXILLOFACCIALEcomputer assisted tomographyESTUDOS PROSPECTIVOSsurgerysafe surgeryPostoperative Complicationssensitivity analysisSevere acute respiratory syndrome coronavirus 2preoperative careVacunacióProspective cohort studyseroprevalenceIncidence (epidemiology)covidElective Surgical Procedures/methodsMiddle Agedcancer gradingCOVID vaccinationoutcome/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_beingSARS-CoV-2; vaccination; surgeryOriginal ArticleFemalecancer surgeryAcademicSubjects/MED00010Life Sciences & BiomedicineAdultCOVID-19 VaccinesAdolescentinternational prospective cohort studyPostoperative Complications/prevention & controlPopulationinfection rateSARS-CoV-2/immunologyNOmodellingYoung Adultmedicinefollow upcancerddc:610infection riskoutcome assessmentLS7_4business.industrySARS-CoV-2Number needed to vaccinatePreoperative careCOVID-193126 Surgery anesthesiology intensive care radiologySettore MED/18Reconstructive and regenerative medicine Radboud Institute for Health Sciences [Radboudumc 10]elective surgeryEmergency medicinebusiness[SDV.MHEP]Life Sciences [q-bio]/Human health and pathologyThe British Journal of Surgery
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Suppression of Penning discharges between the KATRIN spectrometers

2020

The KArlsruhe TRItium Neutrino experiment (KATRIN) aims to determine the effective electron (anti)neutrino mass with a sensitivity of $0.2\textrm{ eV/c}^2$ (90$\%$ C.L.) by precisely measuring the endpoint region of the tritium $\beta$-decay spectrum. It uses a tandem of electrostatic spectrometers working as MAC-E (magnetic adiabatic collimation combined with an electrostatic) filters. In the space between the pre-spectrometer and the main spectrometer, an unavoidable Penning trap is created when the superconducting magnet between the two spectrometers, biased at their respective nominal potentials, is energized. The electrons accumulated in this trap can lead to discharges, which create a…

Speichertechnik - Abteilung BlaumPhysics - Instrumentation and DetectorsPhysics and Astronomy (miscellaneous)Physics::Instrumentation and DetectorsPenning trapFOS: Physical scienceslcsh:AstrophysicsSuperconducting magnetElectronTritiumKATRIN01 natural sciencesNuclear physics0103 physical scienceslcsh:QB460-466lcsh:Nuclear and particle physics. Atomic energy. RadioactivityElectron Captureddc:530[PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det]010306 general physicsNuclear ExperimentEngineering (miscellaneous)PhysicsSpectrometer010308 nuclear & particles physicsPhysicsInstrumentation and Detectors (physics.ins-det)Químicamagnet: superconductivityspectrometer: electrostaticPenning trapBeamlineBeta (plasma physics)electron: backgroundlcsh:QC770-798NeutrinoNeutrino MassKATRIN
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Improved Upper Limit on the Neutrino Mass from a Direct Kinematic Method by KATRIN

2019

We report on the neutrino mass measurement result from the first four-week science run of the Karlsruhe Tritium Neutrino experiment KATRIN in spring 2019. Beta-decay electrons from a high-purity gaseous molecular tritium source are energy analyzed by a high-resolution MAC-E filter. A fit of the integrated electron spectrum over a narrow interval around the kinematic end point at 18.57 keV gives an effective neutrino mass square value of (−1.0−1.1+0.9) eV2. From this, we derive an upper limit of 1.1 eV (90% confidence level) on the absolute mass scale of neutrinos. This value coincides with the KATRIN sensitivity. It improves upon previous mass limits from kinematic measurements by almost a …

Semileptonic decayPhysics - Instrumentation and DetectorsCosmology and Nongalactic Astrophysics (astro-ph.CO)Physics::Instrumentation and DetectorsFOS: Physical sciencesGeneral Physics and AstronomyKinematicsElectron[PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex]KATRIN01 natural sciences7. Clean energyHigh Energy Physics - ExperimentNuclear physicsHigh Energy Physics - Experiment (hep-ex)mass: scaleneutrino: mass: measured0103 physical sciences[PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex]ddc:530S066MAESensitivity (control systems)Limit (mathematics)structure[PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det]Nuclear Experiment (nucl-ex)010306 general physicsNuclear ExperimentPhysicstritiumPhysicsformationS066M2EInstrumentation and Detectors (physics.ins-det)semileptonic decaysensitivityddc:kinematicsElementary Particles and Fieldselectron: energy spectrumHigh Energy Physics::ExperimentPräzisionsexperimente - Abteilung BlaumNeutrino[PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph]Energy (signal processing)Astrophysics - Cosmology and Nongalactic AstrophysicsKATRINexperimental results
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Scientific Proceedings Second International Symposium on Cytostatic Drug Resistance

1991

Cancer Researchmedicine.medical_specialtyOncologybusiness.industrymedicineGeneral MedicineDrug resistancePharmacologyIntensive care medicinebusinessJournal of Cancer Research and Clinical Oncology
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