0000000000347123
AUTHOR
S. Taylor
Evidence for Strange-Quark Contributions to the Nucleon’s Form Factors atQ2=0.108 (GeV/c)2
We report on a measurement of the parity violating asymmetry in the elastic scattering of polarized electrons off unpolarized protons with the A4 apparatus at MAMI in Mainz at a four momentum transfer value of ${Q}^{2}=0.108\text{ }(\mathrm{GeV}/c{)}^{2}$ and at a forward electron scattering angle of $30\ifmmode^\circ\else\textdegree\fi{}l{\ensuremath{\theta}}_{e}l40\ifmmode^\circ\else\textdegree\fi{}$. The measured asymmetry is ${A}_{LR}(\stackrel{\ensuremath{\rightarrow}}{e}p)=[\ensuremath{-}1.36\ifmmode\pm\else\textpm\fi{}0.29(\mathrm{stat})\ifmmode\pm\else\textpm\fi{}0.13(\mathrm{syst})]\ifmmode\times\else\texttimes\fi{}{10}^{\ensuremath{-}6}$. The expectation from the standard model as…
Laser Compton polarimetry at JLab and MAMI
For modern parity violation experiments it is crucial to measure and monitor the electron beam polarization continuously. In the recent years different high-luminosity concepts, for precision Compton backscattering polarimetry, have been developed, to be used at modern CW electron beam accelerator facilities. As Compton backscattering polarimetry is free of intrinsic systematic uncertainties, it can be a superior alternative to other polarimetry techniques such as Moller and Mott scattering. State-of-the-art high-luminosity Compton backscattering designs currently in use and under development at JLab and Mainz are compared to each other. The latest results from the Mainz A4 Compton polarime…
TH-302 + Gemcitabine (G + T) vs Gemcitabine (G) in Patients with Previously Untreated advanced Pancreatic Cancer (PAC)
ABSTRACT Background TH-302 is a hypoxia targeted prodrug with a hypoxia-triggered 2-nitroimidazole component designed to release the DNA alkylator, bromo-isophosphoramide mustard (Br-IPM), when reduced in severe hypoxia. A randomized Phase 2B study (NCT01144455) was conducted to assess the benefit of G + T to standard dose G as first-line therapy of PAC. Materials and methods An open-label multi-center study of two dose levels of TH-302 (240 mg/m2 or 340 mg/m2) in combination with G versus G alone (randomized 1:1:1). G (1000 mg/m2) and T were administered IV over 30-60 minutes on Days 1, 8 and 15 of a 28-day cycle. Patients on the G could crossover after progression and be randomized to a G…
Maximum likelihood ADC parameter estimates improve selection of metastatic cervical nodes for patients with head and neck squamous cell cancer
The aim of this work was to determine whether classification of benign and metastatic cervical nodes based on diffusion weighted imaging (DWI) could be improved by use of a maximum likelihood algorithm for derivation of ADC parameters. A non linear least squares (LSQ) algorithm is usually used to fit parameters to the measured MR signal intensities as a function of b-value. LSQ assumes that the noise in high b-values is normally distributed whereas in reality it follows a Rice distribution. To account for the Rician noise, maximum likelihood (ML) algorithms have been proposed that provide unbiased ADC estimates. In this work the monoexponential, stretched exponential and biexponential model…
Multi-scale analysis of apparent diffusion coefficient (ADC) predicts cervical nodal status in patients with head and neck squamous cell carcinoma
The study assess multi-scale diffusion parameters (median volumetric nodal region of interest values, inter-voxel histogram distributions, and intra-voxel diffusion heterogeneity as assessed by the stretched exponential model) as classifiers of nodal status in patients with head and neck squamous cell carcinoma (SCC). Low b value (0, 50, 100) derived nodal ADC (perfusion sensitive) was the key parameter facilitating discrimination of metastatic from benign nodes in patients with head and neck SCC. The stretched exponential derived α value together with histogram features of ADC provide an accurate decision tree model for classification of nodal disease.
Measurement of the Transverse Beam Spin Asymmetry in Elastic Electron Proton Scattering and the Inelastic Contribution to the Imaginary Part of the Two-Photon Exchange Amplitude
We report on a measurement of the asymmetry in the scattering of transversely polarized electrons off unpolarized protons, A$_\perp$, at two Q$^2$ values of \qsquaredaveragedlow (GeV/c)$^2$ and \qsquaredaveragedhighII (GeV/c)$^2$ and a scattering angle of $30^\circ < ��_e < 40^\circ$. The measured transverse asymmetries are A$_{\perp}$(Q$^2$ = \qsquaredaveragedlow (GeV/c)$^2$) = (\experimentalasymmetry alulowcorr $\pm$ \statisticalerrorlow$_{\rm stat}$ $\pm$ \combinedsyspolerrorlowalucor$_{\rm sys}$) $\times$ 10$^{-6}$ and A$_{\perp}$(Q$^2$ = \qsquaredaveragedhighII (GeV/c)$^2$) = (\experimentalasymme tryaluhighcorr $\pm$ \statisticalerrorhigh$_{\rm stat}$ $\pm$ \combinedsyspolerrorhi…
Measurement of Strange-Quark Contributions to the Nucleon's Form Factors atQ2=0.230 (GeV/c)2
We report on a measurement of the parity-violating asymmetry in the scattering of longitudinally polarized electrons on unpolarized protons at a Q2 of 0.230 (GeV/c)(2) and a scattering angle of theta (e) = 30 degrees - 40 degrees. Using a large acceptance fast PbF2 calorimeter with a solid angle of delta omega = 0.62 sr, the A4 experiment is the first parity violation experiment to count individual scattering events. The measured asymmetry is A(phys)=(-5.44+/-0.54(stat)+/-0.26(sys))x10(-6). The standard model expectation assuming no strangeness contributions to the vector form factors is A(0) = (-6.30+/-0.43) x 10(-6). The difference is a direct measurement of the strangeness contribution t…
Measurement of Strange Quark Contributions to the Vector Form Factors of the Proton atQ2=0.22 (GeV/c)2
A new measurement of the parity violating asymmetry in elastic electron scattering on hydrogen at backward angles and at a four momentum transfer of Q{sup 2}=0.22 (GeV/c){sup 2} is reported here. The measured asymmetry is A{sub LR}=(-17.23{+-}0.82{sub stat}{+-}0.89{sub syst})x10{sup -6}. The standard model prediction assuming no strangeness is A{sub 0}=(-15.87{+-}1.22)x10{sup -6}. In combination with previous results from measurements at forward angles, it is possible to disentangle for the first time the strange form factors at this momentum transfer, G{sub E}{sup s}=0.050{+-}0.038{+-}0.019 and G{sub M}{sup s}=-0.14{+-}0.11{+-}0.11.
Measurements of GEn/GMn from the ^2H(vec{e},e'vec{n})^1H Reaction to Q^2=1.45 (GeV/c)^2
We report new measurements of the ratio of the electric form factor to the magnetic form factor of the neutron, GEn/GMn, obtained via recoil polarimetry from the quasielastic ^2H(vec{e},e'vec{n})^1H reaction at Q^2 values of 0.45, 1.13, and 1.45 (GeV/c)^2 with relative statistical uncertainties of 7.6 and 8.4% at the two higher Q^2 points, which were not reached previously via polarization measurements. Scale and systematic uncertainties are small.
Pharmacological and biochemical study on the effects of selective phosphodiesterase inhibitors on human term myometrium
This study was aimed at evaluating the in vitro effects of phosphodiesterase inhibitors and beta2-adrenoceptor agonists on spontaneous contractions of human term myometrium. Rolipram, RP 73401 (3-cyclopentyloxy-N-(3,5(-dichloro-4-pyridil)-4-methoxybenzamide) and Ro 20-1724 (1-4-(3-butoxy-4-methoxybenzyl)-2-imidozolidinone) (phosphodiesterase 4 inhibitors) inhibited spontaneous myometrial contractions (Emax approximately 100%; pD2 of 6.80+/-0.28, 6.84+/-0.32 and 6.31+/-0.03, respectively). Salbutamol and formoterol were less effective (Emax=40+/-6% and 35+/-12%, respectively) than phosphodiesterase 4 inhibitors to reduce myometrial contractility. Inhibitors of phosphodiesterase 3 (milrinone …