0000000000347211

AUTHOR

Carla Marco-ramírez

showing 7 related works from this author

Sistemas genéticos para un nuevo abordaje del riesgo de progresión de la retinopatía diabética

2016

Resumen Objetivo Evaluar el riesgo de progresion de la retinopatia diabetica (RD) utilizando nuevas estrategias para obtener informacion genetica en diabeticos tipo 2 (DT2) basadas en interferencia por acido ribonucleico (ARN). Material y metodos Estudio multicentrico, prospectivo de casos-controles en 132 participantes divididos en: grupo DT2 (GDT2) con RD (+RD) y sin RD (−RD) (n = 77) y grupo control (GC) (n = 55). Tras entrevista personal y examen oftalmologico, se extrajeron lagrimas para analisis molecular (expresion de micro-ARN [miARN] [miRCURY™ ARN Isolation Kit, Qiagen]). En 18 muestras (GDT2+RD = 6; GDT2–RD = 6; GC = 6) obtuvimos librerias de 137 vs. 140 pares de bases (GeneMapper…

0301 basic medicine03 medical and health sciencesOphthalmology030104 developmental biology0302 clinical medicine030221 ophthalmology & optometryArchivos de la Sociedad Española de Oftalmología
researchProduct

Effects of a nutraceutical formulation based on the combination of antioxidants and ω-3 essential fatty acids in the expression of inflamma…

2013

Maria D Pinazo-Durán,1,* Carmen Galbis-Estrada,1,* Sheila Pons-Vázquez,1 Jorge Cantú-Dibildox,2 Carla Marco-Ramírez,1 Javier Benítez-del-Castillo21Ophthalmic Research Unit Santiago Grisolia, Department of Surgery/Ophthalmology, Faculty of Medicine, University of Valencia, Valencia, Spain; 2Department of Ophthalmology, Hospital of Jerez, Jerez de la Frontera, Spain*These authors contributed equally to this workBackground: Women, and those older than 65 years of age, are particularly susceptible to dry eye disorders (DEDs). Inflammation is clearly involved in the pathogenesis of DEDs, and there is mounting evidence on the antioxidant and …

AdultMaleVascular Endothelial Growth Factor Amedicine.medical_specialtyessential polyunsaturated fatty acidsInterleukin-1betaInflammationnutraceuticsGastroenterologyAntioxidantsPathogenesischemistry.chemical_compoundRisk FactorsInternal medicineFatty Acids Omega-3HumansMedicineProspective StudiesInterleukin 6Prospective cohort studyAgedOriginal ResearchAged 80 and overchemistry.chemical_classificationbiologyInterleukin-6business.industryagingtearsInterleukinGeneral MedicineMiddle AgedcytokinesInterleukin-10Vascular endothelial growth factorchemistryClinical Interventions in AgingDietary SupplementsImmunologybiology.proteinTearsDry Eye SyndromesFemalewomenInflammation MediatorsGeriatrics and Gerontologymedicine.symptombusinessPolyunsaturated fatty acidClinical Interventions in Aging
researchProduct

Oxidative stress and its downstream signaling in aging eyes

2014

María Dolores Pinazo-Durán,1,* Roberto Gallego-Pinazo,2,* Jose Javier García-Medina,1,3,* Vicente Zanón-Moreno,1,4 Carlo Nucci,5 Rosa Dolz-Marco,2 Sebastián Martínez-Castillo,2 Carmen Galbis-Estrada,1 Carla Marco-Ramírez,1 Maria Isabel López-Gálvez,6,* David J Galarreta,6,* Manuel Díaz-Llópis4,*1Ophthalmic Research Unit "Santiago Grisolía", Valencia, Spain; 2Department of Ophthalmology, Macula Section, The University and Polytechnic Hospital La Fe, Valencia, Spain; 3Department of Ophthalmology, University Hospital Reina Sofia, Murcia, Spain; 4Faculty of Medicine, University of Valencia, Spain; 5Uni…

GerontologyAginggenetic structuresGlaucomaDry Eye SyndromesReviewBioinformaticsmedicine.disease_causeEyeRetinal Diseasesophthalmic diseases; antioxidants; epidemiology; oxidative stress; eyes; agingMedicineHumansOcular Physiological PhenomenaPathologicalOcular Physiological PhenomenaAgedMechanism (biology)business.industrySettore MED/30 - Malattie Apparato VisivoRC952-954.6Glaucomaophthalmic diseasesGeneral MedicineDiabetic retinopathyeyesMacular degenerationmedicine.diseaseeye diseasesOxidative stress. Eyes. Aging. Ophthalmic Diseases. Antioxidants. Epidemiology.Oxidative StressantioxidantsGeriatricsDietary SupplementsDry Eye Syndromesepidemiologysense organsGeriatrics and GerontologybusinessOxidative stress
researchProduct

Enhanced Oxidative Stress and Other Potential Biomarkers for Retinopathy in Type 2 Diabetics: Beneficial Effects of the Nutraceutic Supplements

2015

We have studied the global risk of retinopathy in a Mediterranean population of type 2 diabetes mellitus (T2DM) patients, according to clinical, biochemical, and lifestyle biomarkers. The effects of the oral supplementation containing antioxidants/omega 3 fatty acids (A/ω3) were also evaluated. Suitable participants were distributed into two main groups: (1) T2DMG (with retinopathy (+DR) or without retinopathy (−DR)) and (2) controls (CG). Participants were randomly assigned (+A/ω3) or not (−A/ω3) to the oral supplementation with a daily pill of Nutrof Omega (R) for 18 months. Data collected including demographics, anthropometrics, characteristics/lifestyle, ophthalmic examination (best cor…

Blood GlucoseMaleoptical coherenceGlycated Hemoglobin Alcsh:MedicineType 2 diabetesmedicine.disease_causeGastroenterologyAntioxidantschemistry.chemical_compoundMalondialdehyde80 and overglycosylatedAged 80 and overeducation.field_of_studyGeneral MedicineDiabetic retinopathyMiddle AgedMalondialdehydetype 2diabetes mellitusFemaleomega-3Tomography Optical CoherenceResearch ArticleRetinopathyAdultmedicine.medical_specialtyArticle Subjecthemoglobin APopulationtomographyfatty acidsGeneral Biochemistry Genetics and Molecular BiologyInternal medicineFatty Acids Omega-3medicineHumanseducationTriglyceridesAgedGlycated HemoglobinDiabetic RetinopathyGeneral Immunology and MicrobiologySettore MED/30 - Malattie Apparato Visivobusiness.industryadult; aged; aged 80 and over; antioxidants; biomarkers; blood glucose; diabetes mellitus type 2; diabetic retinopathy; fatty acids omega-3; female; hemoglobin A glycosylated; humans; male; malondialdehyde; middle aged; oxidative stress; tomography optical coherence; triglycerides; dietary supplementslcsh:RType 2 Diabetes Mellitusmedicine.diseaseOxidative StressEndocrinologyDiabetes Mellitus Type 2chemistryDietary SupplementsHemoglobinbusinessBiomarkersOxidative stressBioMed Research International
researchProduct

Patients undergoing long-term treatment with antihypertensive eye drops responded positively with respect to their ocular surface disorder to oral su…

2013

Carmen Galbis-Estrada,1,* Maria D Pinazo-Durán,1,* Jorge Cantú-Dibildox,2 Carla Marco-Ramírez,1 Manuel Díaz-Llópis,1,3 Javier Benítez-del-Castillo21Ophthalmic Research Unit Santiago Grisolia, Department of Surgery/Ophthalmology, Faculty of Medicine, University of Valencia, Valencia, Spain; 2Department of Ophthalmology, Hospital of Jerez, Jerez de la Frontera, Cádiz, Spain; 3University and Polytechnic Hospital La Fe, Valencia, Spain*These authors contributed equally to this workBackground: Glaucoma and dry eye disorders (DEDs) are frequent comorbidities. The antioxidant and anti-inflammatory properties of essential …

MalePathologygenetic structuresPhotophobiadry eye disordersAdministration OralDry Eye SyndromesGlaucomaGastroenterologyAntioxidantschemistry.chemical_compoundMedicineProspective StudiesProspective cohort studyOriginal ResearchAged 80 and overchemistry.chemical_classificationGeneral MedicineMiddle AgedFlow CytometryVascular endothelial growth factorTreatment OutcomeFatty Acids UnsaturatedDry Eye SyndromesFemaleChemokinesmedicine.symptomGlaucoma Open-AnglePolyunsaturated fatty acidAdultmedicine.medical_specialtyessential fatty acidsStatistics NonparametricBlurred visionInternal medicineHumansAntihypertensive AgentsAgedbusiness.industrytearsmedicine.diseasecytokineseye diseasesglaucomachemistryClinical Interventions in AgingDietary SupplementsTearssense organsOphthalmic SolutionsGeriatrics and GerontologybusinessBiomarkersClinical Interventions in Aging
researchProduct

Genetic systems for a new approach to risk of progression of diabetic retinopathy.

2016

OBJECTIVE: To evaluate the risk of progression of diabetic retinopathy (DR) using new strategies to obtain genetic information in type 2 diabetes (T2D) based on interfering ribonucleic acid (RNA). MATERIAL AND METHODS: A prospective multicentre case-control study of 132 participants was distributed into: T2D with (+DR) or without (-DR) (T2DG; n=77), and a control group (CG; n=55). After an eye examination and personal interview, tears were collected for molecular analysis (expression of microRNAs [miRNAs] (miRCURY ARN Isolation Kit, Qiagen)]. Libraries, 137 vs. 140bp (GeneMapper, Applied Biosystems), were obtained in 18 samples (T2DG+DR=6; T2DG-DR=6; CG=6) by performing next-generation sequ…

Male0301 basic medicineOncologyMicro RNAsmedicine.medical_specialtyBiomarcadores preclinicosType 2 diabetesMicro-ARNBioinformaticsRisk AssessmentInterference by RNA03 medical and health sciencesDiabetic retinopathyInternal medicineType 2 diabetes mellitusmedicineHumansProspective StudiesFamily historyAgedDiabetic Retinopathymedicine.diagnostic_testSequence Analysis RNAbusiness.industryPre-clinical biomarkersType 2 Diabetes MellitusGenetic systemsRetinopatia diabeticaGeneral MedicineDiabetic retinopathyMiddle Agedmedicine.diseaseInterferencia por ARNMolecular analysisDiabetes mellitus tipo 2030104 developmental biologyDiabetes Mellitus Type 2Eye examinationCase-Control StudiesDisease ProgressionTearsFemalebusinessBiomarcadores preclínicos Diabetes mellitus tipo 2 Diabetic retinopathy Interference by RNA Interferencia por ARN Micro RNAs Micro-ARN Pre-clinical biomarkers Retinopatía diabética Type 2 diabetes mellitus
researchProduct

Ocular Surface and Tear Film Changes in Older Women Working with Computers

2015

The aim of this work is to investigate changes in the ocular surface (OS) and tear film (TF) by means of questionnaire-based subjective symptoms, TF break-up time, Schirmer test, and TF analysis in women working with computers and to analyze the effects of the oral supplementation with antioxidants/omega 3 fatty acids (A/ω3) in the OS outcomes. Women aged 40–65 years (n=148) were recruited at the Administrative Offices of Valencia (Spain) and distributed into two age groups, 40–52 years (AGE1;n=87) and 53–65 years (AGE2;n=61), and then subdivided according to being (or not) computer users (CUG; NCUG) during the workday. Homogeneous subgroups were randomly assigned (or not) to the daily inta…

Adultmedicine.medical_specialtyArticle SubjectDaily intakeInterleukin-1betaDry Eye Syndromeslcsh:MedicineEyeBioinformaticsAntioxidantsGeneral Biochemistry Genetics and Molecular BiologyInternal medicineFatty Acids Omega-3medicineHumansSchirmer testAgedGeneral Immunology and MicrobiologyComputersbusiness.industrylcsh:RGeneral MedicineMiddle AgedMicronutrientSpainHomogeneousTearsPillDietary SupplementsClinical StudyTearsDry Eye SyndromesFemalebusinessOcular surfaceBioMed Research International
researchProduct