0000000000349923

AUTHOR

Antonella Mencacci

showing 2 related works from this author

Molecular epidemiology of KPC-producing Klebsiella pneumoniae from invasive infections in Italy: Increasing diversity with predominance of the ST512 …

2016

Objectives The spread of carbapenem-resistant Enterobacteriaceae (CRE) represents one of the most worrisome problems for clinical medicine worldwide. In Italy, the Antibiotic-Resistance-Istituto Superiore di Sanita surveillance network, in collaboration with the Committee for Antimicrobial Agents of the Italian Society of Clinical Microbiologists, promoted a study to investigate the carbapenem-resistance mechanisms, clonal relatedness and capsular typing of a recent collection of carbapenem-resistant Klebsiella pneumoniae (CR-KP). Methods A total of 17 laboratories distributed across Italy collected all consecutive non-replicate CR-KP isolated from invasive infections during two different s…

0301 basic medicineMicrobiology (medical)gelKlebsiella pneumoniaegenotype030106 microbiologyPopulationcross-sectional studiespulsed-fieldmultilocus sequence typingcross-sectional studies; electrophoresis gel pulsed-field; humans; italy; klebsiella infections; klebsiella pneumoniae; molecular epidemiology; multilocus sequence typing; serogroup; beta-lactamases; genetic variation; genotypeSettore BIO/19 - Microbiologia GeneraleCross-Sectional Studies; Electrophoresis Gel Pulsed-Field; Humans; Italy; Klebsiella Infections; Klebsiella pneumoniae; Molecular Epidemiology; Multilocus Sequence Typing; Serogroup; beta-Lactamases; Genetic Variation; Genotype; Pharmacology; Microbiology (medical); Pharmacology (medical); Infectious Diseasesmolecular epidemiologylaw.inventionMicrobiologybeta-Lactamasebeta-lactamases03 medical and health scienceslawGenotypeitalyPulsed-field gel electrophoresisPharmacology (medical)TypingeducationhumansPolymerase chain reactionPharmacologyCross-Sectional Studieeducation.field_of_studybiologyMolecular epidemiologybiochemical phenomena metabolism and nutritionbiology.organism_classificationSettore MED/07 - Microbiologia e Microbiologia Clinicabacterial infections and mycosesVirologyElectrophoresis Gel Pulsed-Fieldklebsiella pneumoniaeCross-Sectional Studies; Electrophoresis Gel Pulsed-Field; Humans; Italy; Klebsiella Infections; Klebsiella pneumoniae; Molecular Epidemiology; Multilocus Sequence Typing; Serogroup; beta-Lactamases; Genetic Variation; Genotype; Pharmacology; Pharmacology (medical); Infectious DiseasesInfectious Diseasesklebsiella infectionselectrophoresisgenetic variationMultilocus sequence typingserogroupHumanKlebsiella Infection
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Cocirculation of Hajj and non-Hajj strains among serogroup W meningococci in Italy, 2000 to 2016

2019

In Italy, B and C are the predominant serogroups among meningococci causing invasive diseases. Nevertheless, in the period from 2013 to 2016, an increase in serogroup W Neisseria meningitidis (MenW) was observed. This study intends to define the main characteristics of 63 MenW isolates responsible of invasive meningococcal disease (IMD) in Italy from 2000 to 2016. We performed whole genome sequencing on bacterial isolates or single gene sequencing on culture-negative samples to evaluate molecular heterogeneity. Our main finding was the cocirculation of the Hajj and the South American sublineages belonging to MenW/clonal complex (cc)11, which gradually surpassed the MenW/cc22 in Italy. All M…

0301 basic medicineSerotypeMaleCefotaximeinvasive bacterial infectionsEpidemiologymolecular methodsNeisseria meningitidismedicine.disease_causeDisease Outbreaks0302 clinical medicineGenotypemolecular method030212 general & internal medicinenational surveillance systemChildPhylogenyAged 80 and overSurveillanceNeisseria meningitidisitaly; neisseria meningitidis; capsular serogroup w; clonal complex 11; invasive bacterial infections; invasive meningococcal disease; molecular methods; national surveillance systeminvasive bacterial infectionMiddle Aged3. Good healthItalyChild PreschoolPopulation SurveillanceFemalePublic Healthmedicine.drugAdultAdolescentAntibiotic sensitivity030106 microbiologyBiologySerogroup03 medical and health sciencesYoung AdultNeisseria meningitidis Serogroup W-135VirologymedicineNeisseria meningitidiHumanscapsular serogroup WAgedWhole Genome Sequencinginvasive meningococcal diseaseEnvironmental and Occupational HealthPublic Health Environmental and Occupational HealthInfant NewbornInfantSequence Analysis DNAVirologyPenicillinMeningococcal Infectionsclonal complex 11capsular serogroup W; clonal complex 11; invasive bacterial infections; invasive meningococcal disease; Italy; molecular methods; national surveillance system; Neisseria meningitidis; Epidemiology; Public Health Environmental and Occupational Health; VirologyHajjRifampicin
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