0000000000357076

AUTHOR

Oliver Birkholz

showing 3 related works from this author

Composition of a Neuromere and Its Segmental Diversification under the Control ofHoxGenes in the Embryonic CNS ofDrosophila

2014

Studies performed at the level of single, identified cells in the fruitfly Drosophila have decisively contributed to our understanding of the mechanisms underlying the development and function of the nervous system. This review highlights some of the work based on single-cell analyses in the embryonic/larval CNS that sheds light on the principles underlying formation and organization of an entire segmental unit and its divergence along the anterior/posterior body axis.

Central Nervous SystemNervous systemGeneticsbiologyGenes HomeoboxCell lineagebiology.organism_classificationNeuromereEmbryonic stem cellCellular and Molecular Neurosciencemedicine.anatomical_structureBody axisEvolutionary biologyGeneticsmedicineAnimalsDrosophila ProteinsDrosophilaDrosophila (subgenus)Hox geneFunction (biology)Body PatterningJournal of Neurogenetics
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Neuroblast pattern and identity in the Drosophila tail region and role of doublesex in the survival of sex-specific precursors.

2013

The central nervous system is composed of segmental units (neuromeres), the size and complexity of which evolved in correspondence to their functional requirements. In Drosophila, neuromeres develop from populations of neural stem cells (neuroblasts) that delaminate from the early embryonic neuroectoderm in a stereotyped spatial and temporal pattern. Pattern units closely resemble the ground state and are rather invariant in thoracic (T1-T3) and anterior abdominal (A1-A7) segments of the embryonic ventral nerve cord. Here, we provide a comprehensive neuroblast map of the terminal abdominal neuromeres A8-A10, which exhibit a progressively derived character. Compared with thoracic and anterio…

Central Nervous SystemMaleanimal structuresDoublesexSerial homologyApoptosisBiologyNeuroblastNeural Stem CellsAbdomenImage Processing Computer-AssistedAnimalsDrosophila ProteinsCell LineageMolecular BiologyBody PatterningSex CharacteristicsMicroscopy ConfocalNeuroectodermAnatomyNeuromereImmunohistochemistryNeural stem cellCell biologyDNA-Binding ProteinsVentral nerve cordDrosophilaFemaleGanglion mother cellDevelopmental BiologyDevelopment (Cambridge, England)
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Abdominal-B and caudal inhibit the formation of specific neuroblasts in the Drosophila tail region

2013

The central nervous system of Drosophila melanogaster consists of fused segmental units (neuromeres), each generated by a characteristic number of neural stem cells (neuroblasts). In the embryo, thoracic and anterior abdominal neuromeres are almost equally sized and formed by repetitive sets of neuroblasts, whereas the terminal abdominal neuromeres are generated by significantly smaller populations of progenitor cells. Here we investigated the role of the Hox gene Abdominal-B in shaping the terminal neuromeres. We show that the regulatory isoform of Abdominal-B (Abd-B.r) not only confers abdominal fate to specific neuroblasts (e.g. NB6-4) and regulates programmed cell death of several proge…

Central Nervous SystemTailanimal structuresCNS developmentCellular differentiationParaHoxApoptosisBiologyTerminal neuromeresAbdominal-BHox genesNeural Stem CellsNeuroblastNeuroblastsImage Processing Computer-AssistedAnimalsDrosophila ProteinsHox geneMolecular BiologyIn Situ HybridizationDNA PrimersHomeodomain ProteinsfungiCell DifferentiationStem Cells and RegenerationNeuromereImmunohistochemistryMolecular biologyNeural stem cellSegmental patterningDrosophila melanogasterMicroscopy Fluorescencenervous systemembryonic structuresCaudalDrosophilaGanglion mother cellDrosophila ProteinTranscription FactorsDevelopmental BiologyDevelopment
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