Synthesis and structures of some diorganotin bis(hydroxamate)s

Analysis of literature data on the antitumor activity of organotin compounds reveals that R2SnX2 and their complexes containing SnO, SnN or SnS bonds often exhibit biological activity, especially if such bonds are formed by means of intramolecular coordination. Furthermore, a wide range of biological activities, from fungicidal, bactericidal and antiseptic to psychotropic and antitumor, is found to be characteristic for some organic hydroxamic acids (N-acylhydroxylamines). From this point of view the diorgantion bis-hydroxamates in this paper are of particular interest as potential biologically active antitumor drugs. Di-n-butyltin bis(N-methyl-N-p-bromobenzoylhydroxylamine) is being screen…

Organotin(IV) chloride complexes with phosphocholine and dimyristoyl-L-?-phosphatidylcholine

Several complexes of R n SnCl 4-n (R = Me, Ph, n = 1-3; R = nBu, n = 2, 3) with phosphocholine and dimyristoyl-L-α-phosphatidylcholine (phospholipid) have been synthesized and characterized by means of Mossbauer spectroscopy and NMR. Triorganotin chlorides form complexes of (R 3 SnCl) 2 .L stoichiometry with a trigonal bipyramidal pentacoordinate tin environment, while the others form 1:1 complexes with an octahedral hexacoordinate tin environment, with the ligands coordinating through anionic phosphodiester moieties in all cases.

Syntheses and Solid-State Structures of Some Dialkyltin Derivatives of ?-Methoxy- and ?-Acetoxy-phenylacetic Acids

Several di-n-butyltin and diethyltin biscarboxylates and distannoxanes of α-methoxy- and α-acetoxy-phenylacetic acids were synthesized and (two of) their structures were studied by means of X-ray diffraction analysis as well as by means of IR and Mossbauer spectroscopies. It was shown for {[(n-Bu) 2 - SnOC(O)CH(OMe)Ph] 2 O} 2 that there is an interaction between the OMe group and one of the endocyclic tin atoms, resulting in a distorted pentagonal-bipyramidal geometry with the pentagonal plane defined by five O atoms and an uncommon seven coordination number for this tin atom. Spectral data indicate that biscarboxylates have trans-octahedral structures.

Organotin(IV) complexes with tetraethyl ethylene- and propylene-diphosphonates

The series of organotin halide complexes with tetraethyl ethylene- and propylene-diphosphonates R n SnX 4-n .L [n=0, X=Cl; n=1, R=Me, X=Cl, Br; n=1, R=Ph, X=Cl; n=2 R=Me, Et, Bu, X=Cl, Br; n=2, R=Ph, X=Cl; L=(EtO) 2 P(O)CH 2 CHR'P(O)(OEt) 2 , R'=H, Me] were synthesized and characterized by means of NMR and Mossbauer spectroscopy. The crystal structure of the complex of diphenyltin dichloride with propylenediphosphonate was determined. The complex consists of polymer chains with bridging bidentate ligands and an octahedral tin environment containing two types of phosphoryl fragments. All of the R 2 SnX 2 adducts have trans-R 2 SnX 4 geometries of tin coordination octahedra according to the q…

Tin(IV) complexes with O-ethyl(N-ethyl-N,N-dimethylammoniomethyl)phosphonate

Abstract O,O-Diethyl-(N,N-dimethylaminomethyl)phosphonate undergoes ethyl migration leading to O-ethyl-(N-ethyl-N,N-dimethylammoniomethyl)phosphonate (L). Several new complexes of tin(IV) and organotin(IV) chlorides with the title ligand have been synthesized. The stoichiometry of the obtained complexes is as follows: (R3SnCl)2 · L (R=Me, Bu, Ph), R2SnCl2 · L (R=Me, Bu, Ph), RSnCl3 L (R=Me, Ph) and SnCl4 · L. All the complexes have been studied in solution by means of 1H-, 13C-, 31P- and 119Sn-NMR spectroscopy. Their solid state structures have been investigated by means of Mossbauer spectroscopy and the molecular structure of the complex (Ph3SnCl)2 · L has been determined by X-ray crystall…

Complexes of diorganotin(IV) dihalides with diphosphoryl compounds and their Mössbauer spectra