0000000000365055

AUTHOR

J. Pablo Villarroya

showing 2 related works from this author

Crown ethers derived from cyclohexane. Influence of their stereochemistry in complexation and transport

2002

Abstract Crown ethers derived from cyclohexane have been prepared. The trans stereochemistry of the substituents on the carbocyclic ring makes that only one conformation can complex cations. The influence of the stereochemistry in complexation has been studied.

chemistry.chemical_compoundCyclohexanechemistryStereochemistryOrganic ChemistryDrug DiscoveryCrown (botany)Ring (chemistry)BiochemistryTetrahedron
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Synthesis of a New pH-Dependent Ligand: Conformational and Complexation Studies

2003

A new macrocyclic ligand, 3, which exhibits pH-induced conformational changes, has been prepared. This ligand consists of a crown ether derived from a trans-anti-trans 1,2,4,5-tetrasubstituted cyclohexane. Due to the stereochemistry of the substituents on the carbocyclic ring, two different low-energy conformations of the crown ether are possible. Ligand 3 has been studied in solution by 1H NMR spectroscopy at different values of pH and temperature, showing that the conformation of the crown ether, and thus its complexing ability, is strongly pH-dependent. The solid-state structure of the ligand has been determined by X-ray diffraction.

chemistry.chemical_classificationCrystallography1h nmr spectroscopychemistry.chemical_compoundchemistryCyclohexaneStereochemistryPh dependentGeneral ChemistryMacrocyclic ligandLigand (biochemistry)Ring (chemistry)Crown etherSupramolecular Chemistry
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