Papel de la atorvastatina en la prevención del ictus. ¿Puede estar relacionado con su acción sobre la activación plaquetaria? Consideraciones basadas en nuestra propia experiencia

Esta bien establecido que la hipertension arterial es el principal factor de riesgo de ictus y que los pacientes hipertensos presentan frecuentemente otros factores asociados de riesgo vascular, como una mayor activacion plaquetaria. Nuestro grupo de trabajo ha comunicado que determinados farmacos hipotensores, ademas de normalizar las cifras tensionales, disminuyen dicha hiperactivacion plaquetaria, lo que supone un beneficioso efecto anadido, dado el papel que las plaquetas juegan en el proceso aterotrombotico. Actualmente no se ha establecido claramente si la hipercolesterolemia tiene algun papel en el ictus, pero, sin embargo, numerosos autores han demostrado que la administracion de es…

Erythrocyte Membrane Phosphatidylserine Exposure in Obesity

It has been suggested that increased erythrocyte membrane phosphatidylserine (PS) exposure could contribute to hypercoagulability and hemorheological disturbances in obesity. The aim of our study was to evaluate PS exposure in obese patients and in a control group and to correlate this with hemorheological properties, i.e., erythrocyte aggregability (EA) and deformability, and to evaluate the effect of weight loss on these parameters. An anthropometric and analytical evaluation was performed at baseline and after 3 months on a diet (very low-calorie diet for 4 weeks and low-calorie diet for 2 months) on 49 severe or morbid obese patients (37 women, 12 men) and 55 healthy volunteers (39 wome…

Mitochondrial dysfunction, persistent oxidative damage, and catalase inhibition in immune cells of naïve and treated Crohnʼs disease

Background: Oxidative stress is considered a potential etiological factor for Crohn's disease (CD). We characterized the reactive oxygen species (ROS) generated in immune peripheral cells of CD patients, as well as their antioxidant enzyme status and the presence of oxidative damage. In addition, mitochondrial function (ΔΨm) was analyzed to detect the possible origin of ROS. Methods: Cells were obtained from patients at the onset of disease, prior to any treatment. Experiments were repeated when patients were in clinical remission. A set of experiments was carried out in a group of CD patients in persistent morphological remission. Controls were healthy volunteers who were not receiving any…

The lipid composition of red blood cells and their hemorheological behavior in patients with primary hyperlipoproteinemia

Efecto del telmisartán en el estrés oxidativo y actividad antioxidante en leucocitos de sangre periférica de pacientes hipertensos

Resumen Introduccion Se han determinado el estres oxidativo y la actividad enzimatica antioxidante en leucocitos de pacientes hipertensos inmediatamente antes de iniciar el tratamiento con 80 mg/dia de telmisartan y despues de 2 meses de instaurada la medicacion. Adicionalmente se ha valorado en paralelo un grupo control. Material y metodos Como marcador de estres oxidativo, se ha determinado el potencial de membrana mitocondrial (ψΔ) en leucocitos. La actividad antioxidante se ha determinado midiendo la actividad superoxido dismutasa y catalasa en lisados leucocitarios. Resultados Nuestros resultados muestran mayor estres oxidativo y mayor actividad antioxidante en los pacientes en situaci…

Activación plaquetaria e hipercolesterolemia en la patogenia de la trombosis venosa profunda

Currently it is accepted that deep vein thrombosis is a multifactorial event in which the presence of activated platelets and also plasmatic lipids seems to play a pivotal role that it is not well established in the scientific bibliography. Due to the non consensus state about these topics between the different groups working in these aspects, the topic involving deep vein thrombosis-platelets-lipids, and also their interactions, still is an interesting area of investigation, in which it is necessary to carry out studies with the aim of establishing risk factors, initial diagnostic methods and clinical assays to probe the efficacy of new therapies.