0000000000368916

AUTHOR

Luca Longobardo

showing 3 related works from this author

Cardiovascular imaging in the diagnosis and monitoring of cardiotoxicity: Role of echocardiography

2016

The evaluation by cardiovascular imaging of chemotherapy patients became a central topic in the last several years. The use of drugs for the treatment of cancers increased, and new molecules and protocols were developed to improve outcomes in these patients. Although, these novel approaches also produced a progressive increase in side effects, particularly myocardial dysfunction. Imaging of the heart was highly accurate in the early diagnosis of cancer therapeutics related-cardiac dysfunction. Echocardiography is the first-line method to assess ventricular function alterations, and it is required to satisfy the need for an early, easy and accurate diagnosis to stratify the risk of heart fai…

Cardiac function curvemedicine.medical_specialtymedicine.medical_treatmentLeftEchocardiography Three-DimensionalcardiotoxicityAntineoplastic Agents030204 cardiovascular system & hematologychemotherapycancer cardiotoxicity chemotherapy echocardiographyVentricular Function Left03 medical and health sciences0302 clinical medicineInternal medicineNeoplasmsmedicinecancerHumansVentricular FunctionHeart FailureCardiotoxicityChemotherapyVentricular functionbusiness.industryCancerHeartGeneral Medicinemedicine.diseaseEchocardiography Doppler Colorcancer; cardiotoxicity; chemotherapy; echocardiography; Antineoplastic Agents; Cardiotoxicity; Heart; Heart Failure; Humans; Neoplasms; Ventricular Function Left; Early Diagnosis; Echocardiography Three-Dimensionalcancer; cardiotoxicity; echocardiographyEarly DiagnosisCardiovascular DiseasesEchocardiography030220 oncology & carcinogenesisHeart failureThree-DimensionalCardiologyCardiology and Cardiovascular Medicinebusiness
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Anthracyclines and regional myocardial damage in breast cancer patients. A multicentre study from the Working Group on Drug Cardiotoxicity and Cardio…

2021

Abstract Aims In breast cancer (BC) patients treated with anthracyclines-based therapies, we aim at assessing whether adjuvant drugs impact cardiac function differently and whether their cardiotoxicity has a regional pattern. Methods and results In a multicentre study, 146 BC patients (56 ± 11 years) were prospectively enrolled and divided into three groups according to the received treatments: AC/EC-Group (doxorubicin or epirubicin + cyclophosphamide), AC/EC/Tax-Group (AC/EC + taxanes), FEC/Tax-Group (fluorouracil + EC + taxanes). Fifty-six patients of the total cohort also received trastuzumab. Left ventricular ejection fraction (LVEF) and global longitudinal strain (GLS) were calculated …

medicine.medical_specialtymedicine.medical_treatmentPopulationCardiologyBreast NeoplasmsAnthracyclineAnthracyclines; Breast cancer; Cardiotoxicity; Myocardial strain030204 cardiovascular system & hematologyAnthracyclines Breast cancer Breast Neoplasms Cardiology Cardiotoxicity Echocardiography Female Humans italy Myocardial strain Pharmaceutical Preparations Stroke Volume Trastuzumab Ventricular Function Left Ventricular Dysfunction LeftVentricular Function LeftVentricular Dysfunction Left03 medical and health sciencesBreast cancer0302 clinical medicineTrastuzumabInternal medicineHumansMedicineAnthracyclinesRadiology Nuclear Medicine and imagingeducationeducation.field_of_studyChemotherapyCardiotoxicityEjection fractionbusiness.industryStroke VolumeGeneral MedicineTrastuzumabMyocardial strainChemotherapy regimenCardiotoxicityItalyPharmaceutical PreparationsEchocardiographyFluorouracil030220 oncology & carcinogenesisCardiologyFemaleCardiology and Cardiovascular Medicinebusinessmedicine.drugEpirubicinEuropean Heart Journal - Cardiovascular Imaging
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Role of biomarkers in monitoring antiblastic cardiotoxicity

2016

Early detection of anticancer drug-induced cardiotoxicity (CTX) has been evaluated by most international scientific cardiology and oncology societies. High expectations have been placed on the use of specific biomarkers. In recent years, conventional biomarkers and molecules of more recent interest have been tested and compared in the context of anticancer drug-related CTX. Encouraging results were obtained from studies on molecules of myocardial damage, such as troponin and markers of myocardial wall stress, including circulating natriuretic peptides, as well as from the assessment of the products of inflammation or circulating levels of free radicals. However, clear guidelines on their se…

cardiac toxicitymedicine.medical_specialtyantiblasticantineoplasticEarly detectionContext (language use)Antineoplastic Agentsantiblastic; anticancer drugs; antineoplastic; biomarkers; brain natriuretic peptide; cardiac toxicity; troponin; Cardiology and Cardiovascular Medicine030204 cardiovascular system & hematologyBioinformaticsbrain natriuretic peptideSensitivity and Specificity03 medical and health sciencesWall stress0302 clinical medicineCardiac toxicityNeoplasmsNatriuretic Peptide BrainmedicineHumansanticancer drugIntensive care medicineantineoplastic antiblastic anticancer drugs biomarkers brain natriuretic peptide cardiac toxicity troponinMonitoring PhysiologicCardiotoxicitybusiness.industrytroponinbiomarkersGeneral MedicineTime optimalCardiotoxicityanticancer drugsEarly DiagnosisCardiovascular Diseases030220 oncology & carcinogenesisbiomarkerbusinessCardiology and Cardiovascular Medicine
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