0000000000374261
AUTHOR
Läysän Nigamatzyanova
Selective Cytotoxic Activity of Prodigiosin@halloysite Nanoformulation
Prodigiosin, a bioactive secondary metabolite produced by Serratia marcescens, is an effective proapoptotic agent against various cancer cell lines, with little or no toxicity toward normal cells. The hydrophobicity of prodigiosin limits its use for medical and biotechnological applications, these limitations, however, can be overcome by using nanoscale drug carriers, resulting in promising formulations for target delivery systems with great potential for anticancer therapy. Here we report on prodigiosin-loaded halloysite-based nanoformulation and its effects on viability of malignant and non-malignant cells. We have found that prodigiosin-loaded halloysite nanotubes inhibit human epithelia…
Facile Fabrication of Natural Polyelectrolyte-Nanoclay Composites: Halloysite Nanotubes, Nucleotides and DNA Study
Complexation of biopolymers with halloysite nanotubes (HNTs) can greatly affect their applicability as materials building blocks. Here we have performed a systematic investigation of fabrication of halloysite nanotubes complexes with nucleotides and genomic DNA. The binding of DNA and various nucleotide species (polyAU, UMP Na2, ADP Na3, dATP Na, AMP, uridine, ATP Mg) by halloysite nanotubes was tested using UV-spectroscopy. The study revealed that binding of different nucleotides to the nanoclay varied but was low both in the presence and absence of MgCl2, while MgCl2 facilitated significantly the binding of longer molecules such as DNA and polyAU. Modification of the nanotubes with DNA an…
Pickering Emulsion Gels Based on Halloysite Nanotubes and Ionic Biopolymers: Properties and Cleaning Action on Marble Surface
We have fabricated ecocompatible Pickering emulsions based on halloysite nanotubes and ionic biopolymers (chitosan and pectin) from renewable resources. The effect of pectin and chitosan on the Pickering emulsion was investigated by direct visualization of the oil droplets and by the thermodynamic characterization at the interface. Pectin enhances the Pickering emulsion stability, while a phase separation and nonhomogeneous gel was observed in the presence of chitosan. We have demonstrated that the Pickering emulsion in a pectin based gel phase is suitable for wax layer removal from a marble surface. A controlled cleaning is achieved by tuning the contact time between the gel and the marble…