0000000000376864

AUTHOR

Kaisa Karisalmi

showing 2 related works from this author

Model studies on a diastereoselective synthesis of the C(33)–C(37) fragment of Amphotericin B

2003

Abstract A new, short and highly diastereoselective synthetic route aiming at the C(33)–C(37) fragment of Amphotericin B has been developed. Studies with a model aldehyde (benzaldehyde) have given very promising results: the desired stereochemistry of all four stereocenters of the target molecule has been achieved with high diastereoselection. The stereochemistry of three key intermediates and the target segment has been confirmed by X-ray crystallography.

chemistry.chemical_classificationChemistryStereochemistryFragment (computer graphics)Organic ChemistryEnantioselective synthesisBiochemistryAldehydeStereocenterBenzaldehydechemistry.chemical_compoundAldol reactionAmphotericin BDrug DiscoverymedicineMoleculemedicine.drugTetrahedron
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An enantioselective synthesis of the C(33)–C(37) fragment of Amphotericin B

2003

An enantioselective synthesis of the C(33)–C(37) tripropionate fragment of Amphotericin B has been developed in only 6 steps. Peer reviewed

Models MolecularAntifungal Agentsnatural productsFragment (computer graphics)ChemistryStereochemistryasymmetric synthesisOrganic ChemistryEnantioselective synthesisEstersStereoisomerismLigandsBiochemistryStreptomycesorganic chemistryModels ChemicalAmphotericin BAmphotericin BmedicinePhysical and Theoretical Chemistrymedicine.drugOrg. Biomol. Chem.
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