0000000000378477
AUTHOR
W. Lee
European guidelines for quality assurance in colorectal cancer screening and diagnosis: Overview and introduction to the full Supplement publication
Population-based screening for early detection and treatment of colorectal cancer (CRC) and precursor lesions, using evidence-based methods, can be effective in populations with a significant burden of the disease provided the services are of high quality. Multidisciplinary, evidence-based guidelines for quality assurance in CRC screening and diagnosis have been developed by experts in a project co-financed by the European Union. The 450-page guidelines were published in book format by the European Commission in 2010. They include 10 chapters and over 250 recommendations, individually graded according to the strength of the recommendation and the supporting evidence. Adoption of the recomme…
Experimental Realization of a Dirac Monopole through the Decay of an Isolated Monopole
We experimentally observe the decay dynamics of deterministically created isolated monopoles in spin-1 Bose-Einstein condensates. As the condensate undergoes a change between magnetic phases, the isolated monopole gradually evolves into a spin configuration hosting a Dirac monopole in its synthetic magnetic field. We characterize in detail the Dirac monopole by measuring the particle densities of the spin states projected along different quantization axes. Importantly, we observe the spontaneous emergence of nodal lines in the condensate density that accompany the Dirac monopole. We also demonstrate that the monopole decay accelerates in weaker magnetic field gradients.
Synthetic electromagnetic knot in a three-dimensional skyrmion
We experimentally simulate a quantum-mechanical particle interacting with knotted electromagnetic fields.
Effects of Ribavirin Dose Reduction vs Erythropoietin for Boceprevir-Related Anemia in Patients With Chronic Hepatitis C Virus Genotype 1 Infection—A Randomized Trial
International audience; Background & AimsTreatment of hepatitis C virus (HCV) infection with boceprevir, peginterferon, and ribavirin can lead to anemia, which has been managed by reducing ribavirin dose and/or erythropoietin therapy. We assessed the effects of these anemia management strategies on rates of sustained virologic response (SVR) and safety.MethodsPatients (n = 687) received 4 weeks of peginterferon and ribavirin followed by 24 or 44 weeks of boceprevir (800 mg, 3 times each day) plus peginterferon and ribavirin. Patients who became anemic (levels of hemoglobin approximately ≤10 g/dL) during the study treatment period (n = 500) were assigned to groups that were managed by ribavi…