Management of Osteoporosis in Postmenopausal Women

Osteoporosis is a noncommunicable disease with increasing incidence at a global level. The burden of the disease particularly concerns women. A drastic and rapid decline in the circulating levels of estrogens, a key regulator of bone metabolism, is responsible for the increase in bone loss after menopause. Cells with a role in bone metabolism, osteoblasts, osteoclasts and osteocytes, have estrogen receptors. The fall in estrogens increases the differentiation of osteoclasts from progenitors in the bone marrow. A significant expansion in the resorption process follows.

The impact of coffee on health

Abstract Objective Coffee is a beverage used worldwide. It includes a wide array of components that can have potential implication on health. We have reviewed publications on the impact of coffee on a series of health outcomes. Methods Articles published between January 1990 and December 2012 were selected after crossing coffee or caffeine with a list of keywords representative of the most relevant health areas potentially affected by coffee intake. Results Caffeine, chlorogenic acids and diterpenes are important components of coffee. Tolerance often acts as a modulator of the biological actions of coffee. There is a significant impact of coffee on the cardiovascular system, and on the meta…

Reply to Dal Moro

Transient regional osteoporosis.

Transient regional osteoporosis (TRO) is a disease that predisposes to fragility fracture in weight bearing joints of mid-life women and men. Pregnant women may also suffer the process, usually at the hip. The prevalence of TRO is lower than the systemic form, associated with postmenopause and advanced age, but may be falsely diminished by under-diagnosis. The disease may be uni- or bilateral, and may migrate to distinct joints. One main feature of TRO is spontaneous recovery. Pain and progressive limitation in the functionality of the affected joint(s) are key symptoms. In the case of the form associated with pregnancy, difficulties in diagnosis derive from the relatively young age at pres…

Osteoporosis del embarazo

Resumen Este articulo revisa la asociacion entre embarazo y osteoporosis, asi como las dos presentaciones que se encuentran en la practica clinica. Se trata de un problema escasamente investigado, del cual la informacion procede de casos clinicos aislados o de series de casos. Dos formas, posiblemente relacionadas, se describen en la gestacion: la osteoporosis sistemica y la regional. La primera afecta principalmente al hueso trabecular, mientras que la segunda se concentra sobre territorios de carga, frecuentemente la cadera. La fisiopatologia es desconocida, pero probablemente es distinta en ambos casos. No obstante, hay una base comun de susceptibilidad, con osteopenia o franca osteoporo…