0000000000385164
AUTHOR
C. Illueca
Diagnostic value of CD34 immunostaining in desmoplastic trichilemmoma.
Desmoplastic trichilemmoma (DT) is a variant of trichilemmoma, characterized by a central prominent desmoplastic component which may simulate invasive carcinoma. We have studied the morphologic and immunohistochemical features of seven cases of DT. Immunohistochemistry was performed on paraffin sections using monoclonal antibodies to CD34 (QBEND/10), vimentin and GCDFP-15. CD34 was also tested in seven cases of basal cell carcinoma (BCC), three with outer root sheath differentiation and four with morphea-form features, and five squamous cell carcinomas. Histologically, features of conventional trichilemmoma were seen at the periphery of the seven lesions. In contrast, at the center, the epi…
Hipofisitis granulomatosa idiopática. Estudio morfológico e inmunohistoquímico de una observación
Resumen Los procesos inflamatorios de la glandula hipofisaria constituyen un grupo de interes por su escasa frecuencia. Con frecuencia se presentan como lesiones ocupantes de espacio y cursan con cuadros de panhipopituitarismo. Ello platea problemas de diagnostico diferencial con implicaciones terapeuticas importantes En este trabajo presentamos un caso de hipofisitis granulomatosa idiopatica, en una paciente de 55 anos con crisis diarias de cefalea y panhipopituitarismo y un aumento de tamano de la glandula hipofisaria. La morfologia destaca una lesion inflamatoria granulomatosa no necrotizante, con celulas multinu-cleadas gigantes y un infiltrado linfoplasmocitario. El estudio inmunohisto…
Erythrophagocytic tumour cells in melanoma and squamous cell carcinoma of the skin
Aims: Erythrophagocytosis is a characteristic feature of tumour cells in malignant histiocytosis, some leukaemias, lymphomas, and also reactive histiocytes in the haemophagocytic syndrome associated with a variety of infections and neoplasms. It has also been found exceptionally in metastatic malignant epithelial cells in bone marrow and lymph nodes. We present two cases, a cutaneous malignant melanoma and an acantholytic squamous cell carcinoma, in which erythrophagocytosis by tumour cells was demonstrable by both light and electron microscopy. Methods and results: The melanocytic and squamous nature of these cells was supported by the immunohistochemical detection of HMB45, S100, and NKI-…