0000000000388868
AUTHOR
David Thomas
Estimation of power supply harmonic impedance using a controlled voltage disturbance
A novel method for power system impedance estimation is presented. The method employs a power converter to inject a voltage transient onto the supply system. The impedance is estimated through correlation of the measured voltage and current transients. Simulations and experimental results demonstrate the effectiveness of this measurement technique.
A Technique for Power Supply Harmonic Impedance Estimation Using a Controlled Voltage Disturbance
A method for power system impedance estimation is presented. The method employs a power converter to inject a voltage transient onto the supply system. As the technique employs controlled power electronic devices it may be used as a stand alone piece of a portable measurement equipment, or it may be embedded into the functions of an active shunt filter for improved harmonic control. The impedance is estimated through correlation of the measured voltage and current transients. Simulations and experimental results demonstrate the measurement technique is highly accurate and effective.
Characterization of the Clinical and Immunologic Phenotype and Management of 157 Individuals with 56 Distinct Heterozygous NFKB1 Mutations
Contains fulltext : 229571.pdf (Publisher’s version ) (Closed access) BACKGROUND: An increasing number of NFKB1 variants are being identified in patients with heterogeneous immunologic phenotypes. OBJECTIVE: To characterize the clinical and cellular phenotype as well as the management of patients with heterozygous NFKB1 mutations. METHODS: In a worldwide collaborative effort, we evaluated 231 individuals harboring 105 distinct heterozygous NFKB1 variants. To provide evidence for pathogenicity, each variant was assessed in silico; in addition, 32 variants were assessed by functional in vitro testing of nuclear factor of kappa light polypeptide gene enhancer in B cells (NF-κB) signaling. RESU…
Analysis of Heritability and Shared Heritability Based on Genome-Wide Association Studies for Thirteen Cancer Types
BACKGROUND: Studies of related individuals have consistently demonstrated notable familial aggregation of cancer. We aim to estimate the heritability and genetic correlation attributable to the additive effects of common single-nucleotide polymorphisms (SNPs) for cancer at 13 anatomical sites.METHODS: Between 2007 and 2014, the US National Cancer Institute has generated data from genome-wide association studies (GWAS) for 49 492 cancer case patients and 34 131 control patients. We apply novel mixed model methodology (GCTA) to this GWAS data to estimate the heritability of individual cancers, as well as the proportion of heritability attributable to cigarette smoking in smoking-related cance…