Genome-wide association and longitudinal analyses reveal genetic loci linking pubertal height growth, pubertal timing and childhood adiposity

The pubertal height growth spurt is a distinctive feature of childhood growth reflecting both the central onset of puberty and local growth factors. Although little is known about the underlying genetics, growth variability during puberty correlates with adult risks for hormone-dependent cancer and adverse cardiometabolic health. The only gene so far associated with pubertal height growth, LIN28B, pleiotropically influences childhood growth, puberty and cancer progression, pointing to shared underlying mechanisms. To discover genetic loci influencing pubertal height and growth and to place them in context of overall growth and maturation, we performed genome-wide association meta-analyses i…

Chernobyl exposure as stressor during offspring pregnancy and hormone levels in adolescent.

H�moperfusion durch verkapselte Aktivkohle zur Therapie exogener und endogener Intoxikationen

Die von Chang entwickelte Methode, artefizielle Zellen — in Kollodium und Albumin verkapselte Aktivkohle — zur Hamoperfusion einzusetzen, wurde in vitro studiert. Gepruft wurde die Kapazitat zur Adsorption von schlecht wie gut dialysablen Substanzen (Barbiturate, Diazepam, Parathion) und einem endogen toxischen Metaboliten (p-Hydroxyphenylessigsaure). — Mit der Adsorptions-Einheit lassen sich in 90 min 80–90% der Ausgangskonzentrationen von Barbiturat, Diazepam und p-Hydroxyphenylacetat eliminieren, von Parathion etwa 50%, Bromid und Ammoniak werden nicht adsorbiert. Versuche, durch den Einbau von Heparin in die Hulle der Kohlegranula die regionale Heparinisierung unnotig zu machen, waren e…

Ketone body 3-hydroxybutyrate as a biomarker of aggression

Human aggression is a complex behaviour, the biological underpinnings of which remain poorly known. To gain insights into aggression biology, we studied relationships with aggression of 11 low-molecular-weight metabolites (amino acids, ketone bodies), processed using 1H nuclear magnetic resonance spectroscopy. We used a discovery sample of young adults and an independent adult replication sample. We studied 725 young adults from a population-based Finnish twin cohort born 1983–1987, with aggression levels rated in adolescence (ages 12, 14, 17) by multiple raters and blood plasma samples at age 22. Linear regression models specified metabolites as the response variable and aggression ratings…