0000000000403159
AUTHOR
Michael Strupp
showing 6 related works from this author
Torsional eye movement responses to monaural and binaural galvanic vestibular stimulation: side-to-side asymmetries.
2003
Vestibular stimulation by head accelerations always involves multisensory activation of the vestibular, somatosensory, and visual systems. Over the past few years, galvanic vestibular stimulation (GVS) has become increasingly popular for testing vestibular function for clinical and research purposes. Although GVS provides a nonphysiological stimulation, it is more selective than natural head accelerations and is thus an attractive tool for such tests. Eye movement responses elicited by GVS mainly consist of torsional and horizontal components, as first described by Hitzig in 1871. Animal experiments have shown that GVS increases the vestibular afferent spike frequency at the cathodal site a…
Corrigendum to “A multicenter observational study on the role of comorbidities in the recurrent episodes of benign paroxysmal positional vertigo” [Au…
2014
Alessandro De Stefano *, Francesco Dispenza , Hamlet Suarez , Nicolas Perez-Fernandez , Raquel Manrique-Huarte , Jae Ho Ban , Min-Beom Kim , Michael Strupp , Katharina Feil , Carlos A. Oliveira , Andres L. Sampaio , Mercedes F.S. Araujo , Fayez Bahmad Jr., Mauricio M. Gananca , Fernando F. Gananca , Ricardo Dorigueto , Hyung Lee , Gautham Kulamarva , Navneet Mathur , Pamela Di Giovanni , Anna Grazia Petrucci , Tommaso Staniscia , Leonardo Citraro , Adelchi Croce a
Immunosuppressive treatment in bilateral vestibulopathy with inner ear antibodies.
2005
Although vestibular recovery was observed after steroid treatment, it remains uncertain whether this improvement was spontaneous or due to medication. These data do not allow us to generally recommend corticosteroid treatment in patients with BVF and inner ear antibodies.A retrospective study was performed based on the observation of two patients with suspected autoimmune bilateral vestibular failure (BVF) with normal hearing and antilabyrinthine or nervous tissue-specific serum antibodies who showed vestibular recovery after corticosteroid treatment.Twelve patients with BVF and serum inner ear antibodies who had received imuunosuppressive treatment with corticosteroids were evaluated in te…
Acetyl-dl-leucine in Niemann-Pick type C
2015
Objective: To assess the effects of the modified amino acid acetyl-dl-leucine (AL) on cerebellar ataxia, eye movements, and quality of life of patients with Niemann-Pick type C (NP-C) disease. Methods: Twelve patients with NP-C disease were treated with AL 3 g/d for 1 week and then with 5 g/d for 3 weeks with a subsequent washout period of 1 month. The Scale for the Assessment and Rating of Ataxia (SARA), the Spinocerebellar Ataxia Functional Index (SCAFI), the modified Disability Rating Scale (mDRS), EuroQol 5Q-5D-5L, and the visual analog scale (VAS) were administered. Measurements took place at baseline, after 1 month of therapy, and after 1 month of washout. Results: The SARA score chan…
Zentrale vestibuläre Schwindelformen
2004
Zentrale vestibulare Schwindelformen entstehen durch Lasionen entlang der vestibularen Verbindungen von den Vestibulariskernen in der Medulla oblongata zu den okulomotorischen Kernen und Integrationszentren im rostralen Mittelhirn sowie zum Vestibulozerebellum, Thalamus und vestibularen Kortex im temporoparietalen Groshirn (Brandt und Dieterich 1995). Es handelt sich oft um klar definierte klinische Syndrome unterschiedlicher Atiologie, deren typische Befunde aus Okulomotorik, Wahrnehmung und Haltungsregulation eine topische Hirnstammdiagnostik erlauben. Die Analyse des Nystagmus kann fur die lokalisatorische Zuordnung hilfreich sein (Buttner et al. 1995). Auf diese typischen Befunde soll h…
Ocular motor biomarkers in Niemann-Pick disease type C: A prospective cross-sectional multicontinental study in 72 patients
2020
AbstractNiemann-Pick type C (NPC) is a rare lysosomal storage disorder with ocular motor involvement. In a multicontinental, cross-sectional study we characterized ocular motor function in 72 genetically proven patients from twelve countries by means of video-oculography. Interlinking with disease severity, we also searched for ocular motor biomarkers. Our study protocol comprised reflexive and self-paced saccades, smooth pursuit, and gaze-holding in horizontal and vertical planes. Data were compared with those of 158 healthy controls. The Modified Disability Rating Scale, Scale for Assessment and Rating of Ataxia, Spinocerebellar Ataxia Functional Index for neurological status, and Montrea…