0000000000403457

AUTHOR

María I. López-gálvez

showing 3 related works from this author

Oxidative stress and its downstream signaling in aging eyes

2014

María Dolores Pinazo-Durán,1,* Roberto Gallego-Pinazo,2,* Jose Javier García-Medina,1,3,* Vicente Zanón-Moreno,1,4 Carlo Nucci,5 Rosa Dolz-Marco,2 Sebastián Martínez-Castillo,2 Carmen Galbis-Estrada,1 Carla Marco-Ramírez,1 Maria Isabel López-Gálvez,6,* David J Galarreta,6,* Manuel Díaz-Llópis4,*1Ophthalmic Research Unit "Santiago Grisolía", Valencia, Spain; 2Department of Ophthalmology, Macula Section, The University and Polytechnic Hospital La Fe, Valencia, Spain; 3Department of Ophthalmology, University Hospital Reina Sofia, Murcia, Spain; 4Faculty of Medicine, University of Valencia, Spain; 5Uni…

GerontologyAginggenetic structuresGlaucomaDry Eye SyndromesReviewBioinformaticsmedicine.disease_causeEyeRetinal Diseasesophthalmic diseases; antioxidants; epidemiology; oxidative stress; eyes; agingMedicineHumansOcular Physiological PhenomenaPathologicalOcular Physiological PhenomenaAgedMechanism (biology)business.industrySettore MED/30 - Malattie Apparato VisivoRC952-954.6Glaucomaophthalmic diseasesGeneral MedicineDiabetic retinopathyeyesMacular degenerationmedicine.diseaseeye diseasesOxidative stress. Eyes. Aging. Ophthalmic Diseases. Antioxidants. Epidemiology.Oxidative StressantioxidantsGeriatricsDietary SupplementsDry Eye Syndromesepidemiologysense organsGeriatrics and GerontologybusinessOxidative stress
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Enhanced Oxidative Stress and Other Potential Biomarkers for Retinopathy in Type 2 Diabetics: Beneficial Effects of the Nutraceutic Supplements

2015

We have studied the global risk of retinopathy in a Mediterranean population of type 2 diabetes mellitus (T2DM) patients, according to clinical, biochemical, and lifestyle biomarkers. The effects of the oral supplementation containing antioxidants/omega 3 fatty acids (A/ω3) were also evaluated. Suitable participants were distributed into two main groups: (1) T2DMG (with retinopathy (+DR) or without retinopathy (−DR)) and (2) controls (CG). Participants were randomly assigned (+A/ω3) or not (−A/ω3) to the oral supplementation with a daily pill of Nutrof Omega (R) for 18 months. Data collected including demographics, anthropometrics, characteristics/lifestyle, ophthalmic examination (best cor…

Blood GlucoseMaleoptical coherenceGlycated Hemoglobin Alcsh:MedicineType 2 diabetesmedicine.disease_causeGastroenterologyAntioxidantschemistry.chemical_compoundMalondialdehyde80 and overglycosylatedAged 80 and overeducation.field_of_studyGeneral MedicineDiabetic retinopathyMiddle AgedMalondialdehydetype 2diabetes mellitusFemaleomega-3Tomography Optical CoherenceResearch ArticleRetinopathyAdultmedicine.medical_specialtyArticle Subjecthemoglobin APopulationtomographyfatty acidsGeneral Biochemistry Genetics and Molecular BiologyInternal medicineFatty Acids Omega-3medicineHumanseducationTriglyceridesAgedGlycated HemoglobinDiabetic RetinopathyGeneral Immunology and MicrobiologySettore MED/30 - Malattie Apparato Visivobusiness.industryadult; aged; aged 80 and over; antioxidants; biomarkers; blood glucose; diabetes mellitus type 2; diabetic retinopathy; fatty acids omega-3; female; hemoglobin A glycosylated; humans; male; malondialdehyde; middle aged; oxidative stress; tomography optical coherence; triglycerides; dietary supplementslcsh:RType 2 Diabetes Mellitusmedicine.diseaseOxidative StressEndocrinologyDiabetes Mellitus Type 2chemistryDietary SupplementsHemoglobinbusinessBiomarkersOxidative stressBioMed Research International
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Clinical and Molecular-Genetic Insights into the Role of Oxidative Stress in Diabetic Retinopathy: Antioxidant Strategies and Future Avenues

2020

Reactive oxygen species (ROS) overproduction and ROS-signaling pathways activation attack the eyes. We evaluated the oxidative stress (OS) and the effects of a daily, core nutritional supplement regimen containing antioxidants and omega 3 fatty acids (A/ω3) in type 2 diabetics (T2DM). A case-control study was carried out in 480 participants [287 T2DM patients with (+)/without (−) diabetic retinopathy (DR) and 193 healthy controls (CG)], randomly assigned to a daily pill of A/ω3. Periodic evaluation through 38 months allowed to outline patient characteristics, DR features, and classic/OS blood parameters. Statistics were performed by the SPSS 24.0 program. Diabetics displayed significantly h…

medicine.medical_specialtyAntioxidanttype 2 diabetes mellitusPhysiologyThiobarbituric acidmedicine.medical_treatmentClinical BiochemistryDietética y nutrición030209 endocrinology & metabolismmedicine.disease_causeBiochemistryArticle03 medical and health scienceschemistry.chemical_compound0302 clinical medicineprevention of blindnessInternal medicineretinopathymedicineTBARSoxidative stressMolecular Biologyomega-3 fatty acidsVitamin Cbusiness.industrylcsh:RM1-950Cell BiologyDiabetic retinopathymedicine.diseaseMalondialdehydeAnatomía ocularlcsh:Therapeutics. PharmacologyantioxidantsEndocrinologychemistrycandidate biomarkers030221 ophthalmology & optometryOftalmologíabusinessOxidative stressRetinopathy
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