6533b854fe1ef96bd12ae0da

RESEARCH PRODUCT

Clinical and Molecular-Genetic Insights into the Role of Oxidative Stress in Diabetic Retinopathy: Antioxidant Strategies and Future Avenues

Vicente Zanon-morenoJ. Fernando ArevaloMaria D Pinazo-duranMaria D Pinazo-duranMar Valero-velloSilvia M. Sanz-gonzálezSilvia M. Sanz-gonzálezAna I. RamírezAna I. RamírezL. DuarteDavid Galarreta-miraJose Javier Garcia-medinaMaría I. López-gálvez

subject

medicine.medical_specialtyAntioxidanttype 2 diabetes mellitusPhysiologyThiobarbituric acidmedicine.medical_treatmentClinical BiochemistryDietética y nutrición030209 endocrinology & metabolismmedicine.disease_causeBiochemistryArticle03 medical and health scienceschemistry.chemical_compound0302 clinical medicineprevention of blindnessInternal medicineretinopathymedicineTBARSoxidative stressMolecular Biologyomega-3 fatty acidsVitamin Cbusiness.industrylcsh:RM1-950Cell BiologyDiabetic retinopathymedicine.diseaseMalondialdehydeAnatomía ocularlcsh:Therapeutics. PharmacologyantioxidantsEndocrinologychemistrycandidate biomarkers030221 ophthalmology & optometryOftalmologíabusinessOxidative stressRetinopathy

description

Reactive oxygen species (ROS) overproduction and ROS-signaling pathways activation attack the eyes. We evaluated the oxidative stress (OS) and the effects of a daily, core nutritional supplement regimen containing antioxidants and omega 3 fatty acids (A/ω3) in type 2 diabetics (T2DM). A case-control study was carried out in 480 participants [287 T2DM patients with (+)/without (−) diabetic retinopathy (DR) and 193 healthy controls (CG)], randomly assigned to a daily pill of A/ω3. Periodic evaluation through 38 months allowed to outline patient characteristics, DR features, and classic/OS blood parameters. Statistics were performed by the SPSS 24.0 program. Diabetics displayed significantly higher circulating pro-oxidants (p = 0.001) and lower antioxidants (p = 0.0001) than the controls. Significantly higher plasma malondialdehyde/thiobarbituric acid reactive substances (MDA/TBARS

yearjournalcountryeditionlanguage
2020-11-09
10.3390/antiox9111101