0000000000403458

AUTHOR

Carlo Nucci

showing 5 related works from this author

Oxidative stress and its downstream signaling in aging eyes

2014

María Dolores Pinazo-Durán,1,* Roberto Gallego-Pinazo,2,* Jose Javier García-Medina,1,3,* Vicente Zanón-Moreno,1,4 Carlo Nucci,5 Rosa Dolz-Marco,2 Sebastián Martínez-Castillo,2 Carmen Galbis-Estrada,1 Carla Marco-Ramírez,1 Maria Isabel López-Gálvez,6,* David J Galarreta,6,* Manuel Díaz-Llópis4,*1Ophthalmic Research Unit "Santiago Grisolía", Valencia, Spain; 2Department of Ophthalmology, Macula Section, The University and Polytechnic Hospital La Fe, Valencia, Spain; 3Department of Ophthalmology, University Hospital Reina Sofia, Murcia, Spain; 4Faculty of Medicine, University of Valencia, Spain; 5Uni…

GerontologyAginggenetic structuresGlaucomaDry Eye SyndromesReviewBioinformaticsmedicine.disease_causeEyeRetinal Diseasesophthalmic diseases; antioxidants; epidemiology; oxidative stress; eyes; agingMedicineHumansOcular Physiological PhenomenaPathologicalOcular Physiological PhenomenaAgedMechanism (biology)business.industrySettore MED/30 - Malattie Apparato VisivoRC952-954.6Glaucomaophthalmic diseasesGeneral MedicineDiabetic retinopathyeyesMacular degenerationmedicine.diseaseeye diseasesOxidative stress. Eyes. Aging. Ophthalmic Diseases. Antioxidants. Epidemiology.Oxidative StressantioxidantsGeriatricsDietary SupplementsDry Eye Syndromesepidemiologysense organsGeriatrics and GerontologybusinessOxidative stress
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Enhanced Oxidative Stress and Other Potential Biomarkers for Retinopathy in Type 2 Diabetics: Beneficial Effects of the Nutraceutic Supplements

2015

We have studied the global risk of retinopathy in a Mediterranean population of type 2 diabetes mellitus (T2DM) patients, according to clinical, biochemical, and lifestyle biomarkers. The effects of the oral supplementation containing antioxidants/omega 3 fatty acids (A/ω3) were also evaluated. Suitable participants were distributed into two main groups: (1) T2DMG (with retinopathy (+DR) or without retinopathy (−DR)) and (2) controls (CG). Participants were randomly assigned (+A/ω3) or not (−A/ω3) to the oral supplementation with a daily pill of Nutrof Omega (R) for 18 months. Data collected including demographics, anthropometrics, characteristics/lifestyle, ophthalmic examination (best cor…

Blood GlucoseMaleoptical coherenceGlycated Hemoglobin Alcsh:MedicineType 2 diabetesmedicine.disease_causeGastroenterologyAntioxidantschemistry.chemical_compoundMalondialdehyde80 and overglycosylatedAged 80 and overeducation.field_of_studyGeneral MedicineDiabetic retinopathyMiddle AgedMalondialdehydetype 2diabetes mellitusFemaleomega-3Tomography Optical CoherenceResearch ArticleRetinopathyAdultmedicine.medical_specialtyArticle Subjecthemoglobin APopulationtomographyfatty acidsGeneral Biochemistry Genetics and Molecular BiologyInternal medicineFatty Acids Omega-3medicineHumanseducationTriglyceridesAgedGlycated HemoglobinDiabetic RetinopathyGeneral Immunology and MicrobiologySettore MED/30 - Malattie Apparato Visivobusiness.industryadult; aged; aged 80 and over; antioxidants; biomarkers; blood glucose; diabetes mellitus type 2; diabetic retinopathy; fatty acids omega-3; female; hemoglobin A glycosylated; humans; male; malondialdehyde; middle aged; oxidative stress; tomography optical coherence; triglycerides; dietary supplementslcsh:RType 2 Diabetes Mellitusmedicine.diseaseOxidative StressEndocrinologyDiabetes Mellitus Type 2chemistryDietary SupplementsHemoglobinbusinessBiomarkersOxidative stressBioMed Research International
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Ocular Comorbidities and the Relationship between Eye Diseases and Systemic Disorders

2016

Patients with ocular disorders may have additional ophthalmic problems that can have an impact on both morbidity and vision. Ocular comorbidities are commonly associated with vision-related disability and decreased quality of life related to visual impairment. The majority of studies on this topic deal with cataracts, glaucoma, uveitis, and/or retinopathies. It is important to summarize the available evidence to date on the association of one or several ocular diseases and the implications these comorbidities have on prognosis and therapy. The relationship between eye disorders and systemic diseases has recently drawn special interest. The increasing prevalence of neurodegenerative disorder…

Cardiovascular Diseases; Diabetes Complications; Eye; Eye Diseases; Humans; Joint Diseases; Models Biological; Neurodegenerative DiseasesPediatricsmedicine.medical_specialtyIntraocular pressureEye DiseasesArticle Subjectgenetic structuresPopulationlcsh:MedicineGlaucomaEyeGeneral Biochemistry Genetics and Molecular BiologyDiabetes ComplicationsCataractsModelsOphthalmologymedicineHumanseducationeducation.field_of_studyGeneral Immunology and MicrobiologySettore MED/30 - Malattie Apparato Visivobusiness.industrylcsh:RNeurodegenerative DiseasesGeneral MedicineDiabetic retinopathyBiologicalmedicine.diseaseComorbidityeye diseasesEditorialCardiovascular DiseasesEye disordersense organsJoint DiseasesbusinessUveitisBioMed Research International
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Direct costs of glaucoma and severity of the disease: a multinational long term study of resource utilisation in Europe

2005

International audience; Background: Resource utilisation and direct costs associated with glaucoma progression in Europe are unknown. As population progressively ages, the economic impact of the disease will increase. Methods: From a total of 1655 consecutive cases, the records of 194 patients were selected and stratified by disease severity. Record selection was based on diagnoses of primary open angle glaucoma, glaucoma suspect, ocular hypertension, or normal tension glaucoma; 5 years minimum follow up were required. Glaucoma severity was assessed using a six stage glaucoma staging system based on static threshold visual field parameters. Resource utilisation data were abstracted from the…

Maleage distributionOrganes des sensgenetic structuresOffice VisitsOcular hypertensionGlaucomaDiseaseintraocular hypertensionSeverity of Illness IndexIndirect costs0302 clinical medicineambulatory careNormal tension glaucomamiddle agedopen angle glaucoma80 and overMedicine030212 general & internal medicinepathophysiologystatistical significanceAged 80 and overeducation.field_of_studyadultdisease coursearticlehealth care costclinical trialHealth Care Costshealth care planningSensory Systems3. Good healthEuropeagedfemalepriority journalstatisticsHealth Resourcesdisease severityadult; aged; article; disease course; disease severity; Europe; female; follow up; general practitioner; glaucoma; health care cost; health care utilization; human; intraocular hypertension; major clinical study; male; medical record; open angle glaucoma; priority journal; statistical significance; visual field; age distribution; ambulatory care; clinical trial; drug cost; economics; health care planning; hospitalization; middle aged; multicenter study; pathophysiology; sex ratio; statistics; utilization review; Adult; Age Distribution; Aged; Aged 80 and over; Drug Costs; Europe; Female; Follow-Up Studies; Glaucoma; Health Care Costs; Health Resources; Humans; Male; Middle Aged; Office Visits; Severity of Illness Index; Sex Distribution; Visual Fieldshospitalizationvisual fieldWorld Viewsmedicine.medical_specialtyOpen angle glaucomadrug costPopulationSensory OrgansMédecine humaine et pathologiemedical recordDrug Costs03 medical and health sciencesCellular and Molecular Neurosciencehealth care utilizationSeverity of illnessfollow upHumanshumanSex Distribution[SDV.MHEP.OS]Life Sciences [q-bio]/Human health and pathology/Sensory Organseducationutilization reviewSettore MED/30 - Malattie Apparato Visivobusiness.industryGlaucomaeconomicssex ratiomedicine.diseasemajor clinical studyeye diseasesOphthalmologymulticenter studygeneral practitionerEmergency medicine030221 ophthalmology & optometryOptometryHuman health and pathologyVisual Fieldsbusiness[SDV.MHEP]Life Sciences [q-bio]/Human health and pathologyFollow-Up Studies
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Eclectic Ocular Comorbidities and Systemic Diseases with Eye Involvement: A Review.

2016

Coexistence of several ocular diseases is more frequent than suspected. In spite of the refractive errors, one or more of the following can be detected simultaneously: glaucoma, cataracts, uveitis, age-related macular degeneration, and dry eyes. In addition, as people age, ocular comorbidities are much more usually seen. Specific diseases are openly acknowledged to affect the eyes and vision, such as diabetes mellitus, hypertension blood pressure, arthritis, hyperthyroidism, neurodegenerative disorders, hematologic malignancies, and/or systemic infections. Recent advances in early diagnosis and therapy of the ophthalmic pathologies have reinforced patient options to prevent visual impairmen…

medicine.medical_specialtygenetic structuresVisual impairmentGlaucomalcsh:MedicineContext (language use)Review ArticleGeneral Biochemistry Genetics and Molecular Biologycomorbidity; humans; eye diseases03 medical and health sciences0302 clinical medicineCataractsDiabetes mellitusmedicineIntensive care medicinehumansGeneral Immunology and Microbiologybusiness.industrySettore MED/30 - Malattie Apparato Visivolcsh:Reye diseasesGeneral MedicineMacular degenerationmedicine.diseaseComorbidityeye diseasescomorbidity030221 ophthalmology & optometryPhysical therapysense organsmedicine.symptombusiness030217 neurology & neurosurgeryUveitis
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