0000000000405040

AUTHOR

Patrizio Odetti

showing 7 related works from this author

Preoperative risk factors for postoperative delirium (POD) after urological surgery in the elderly

2011

The aim of this observational study was to investigate the occurrence of postoperative delirium (POD) in elderly patients undergoing urological surgery and to identify those factors associated with delirium. Ninety consecutive patients (81 males and 9 females; average age of 74.3 ± 0.40 years), undergoing urological surgery in University-Hospital Urological Clinic were selected. Personal, medical, cognitive and functional data, biochemical parameters, preoperative medications, conduct of surgery and anesthesia and details of hemodynamic control were collected as predictors of delirium. After surgery, the subjects were divided on the basis of delirium onset within a week observation period. …

Malemedicine.medical_specialtyAgingHealth (social science)Activities of daily livingPreoperative riskHemodynamicsbehavioral disciplines and activitiesCohort StudiesPostoperative ComplicationsCognitionRisk FactorsInternal medicinemental disordersActivities of Daily LivingHumansMedicinePostoperative deliriumGeriatric AssessmentAgedDelirium; Hypotension; Multidimensional assessment; Older people; Urological surgerybusiness.industryRisk FactorUrological surgeryDeliriumUrological surgerynervous system diseasesAnesthesiaDeliriumUrologic Surgical ProceduresObservational studyFemalePostoperative ComplicationGeriatrics and Gerontologymedicine.symptomHypotensionOlder peopleCohort StudiebusinessGerontologyClock drawing testMultidimensional assessmentHuman
researchProduct

A Periodic Diet that Mimics Fasting Promotes Multi-System Regeneration, Enhanced Cognitive Performance, and Healthspan

2015

SummaryProlonged fasting (PF) promotes stress resistance, but its effects on longevity are poorly understood. We show that alternating PF and nutrient-rich medium extended yeast lifespan independently of established pro-longevity genes. In mice, 4 days of a diet that mimics fasting (FMD), developed to minimize the burden of PF, decreased the size of multiple organs/systems, an effect followed upon re-feeding by an elevated number of progenitor and stem cells and regeneration. Bi-monthly FMD cycles started at middle age extended longevity, lowered visceral fat, reduced cancer incidence and skin lesions, rejuvenated the immune system, and retarded bone mineral density loss. In old mice, FMD c…

MaleAbdominal Fat; Adult; Aged; Aging; Animals; Body Weight; Cardiovascular Diseases; Diet; Female; Humans; Male; Mice; Mice Inbred C57BL; Middle Aged; Neoplasms; Neurogenesis; Pilot Projects; Psychomotor Performance; Regeneration; Saccharomyces cerevisiae; Young Adult; Cognition; Fasting; LongevityAgingPhysiologyPilot ProjectsMiceCognitionNeoplasmsCardiovascular DiseaseSettore MED/49 - Scienze Tecniche Dietetiche Applicatemedia_common2. Zero hungerNeurogenesisLongevityFastingMiddle Aged3. Good healthCardiovascular DiseasesFemaleStem cellHumanAdultmedicine.medical_specialtyNeurogenesismedia_common.quotation_subjectLongevityAbdominal FatSaccharomyces cerevisiaeBiologyArticleYoung AdultImmune systemInternal medicineDiabetes mellitusmedicineAnimalsHumansRegenerationPilot ProjectAdverse effectCell Biology; Molecular Biology; PhysiologyMolecular BiologyAgedAnimalBody WeightCell Biologymedicine.diseaseMiddle ageDietMice Inbred C57BLEndocrinologyCancer cellNeoplasmNeurogenesiPsychomotor Performance
researchProduct

Appropriateness of oral anticoagulant therapy prescription and its associated factors in hospitalized older people with atrial fibrillation

2018

Aims Although oral anticoagulants (OACs) are effective in preventing stroke in older people with atrial fibrillation (AF), they are often underused in this particularly high-risk population. The aim of the present study was to assess the appropriateness of OAC prescription and its associated factors in hospitalized patients aged 65 years or older. Methods Data were obtained from the retrospective phase of Simulation-based Technologies to Improve the Appropriate Use of Oral Anticoagulants in Hospitalized Elderly Patients With Atrial Fibrillation (SIM-AF) study, held in 32 Italian internal medicine and geriatric wards. The appropriateness of OAC prescription was assessed, grouping patients in…

Pharmacologymedicine.medical_specialtyeducation.field_of_studybusiness.industryPopulationAtrial fibrillation030204 cardiovascular system & hematologymedicine.diseaseLogistic regression03 medical and health sciences0302 clinical medicineEmergency medicineAntithromboticmedicineOral anticoagulantPharmacology (medical)030212 general & internal medicineMedical prescriptionOlder peopleeducationbusinessStrokeBritish Journal of Clinical Pharmacology
researchProduct

Appropriateness of oral anticoagulant therapy prescription and its associated factors in hospitalized older people with atrial fibrillation

2018

Aims: Although oral anticoagulants (OACs) are effective in preventing stroke in older people with atrial fibrillation (AF), they are often underused in this particularly high-risk population. The aim of the present study was to assess the appropriateness of OAC prescription and its associated factors in hospitalized patients aged 65 years or older. Methods: Data were obtained from the retrospective phase of Simulation-based Technologies to Improve the Appropriate Use of Oral Anticoagulants in Hospitalized Elderly Patients With Atrial Fibrillation (SIM-AF) study, held in 32 Italian internal medicine and geriatric wards. The appropriateness of OAC prescription was assessed, grouping patients …

MaleOralappropriateness of prescriptionappropriateness of prescription atrial fibrillation internal medicine geriatric wards older patients oral anticoagulantSocio-culturaleAdministration OralHemorrhageInappropriate PrescribingDrug Prescriptionsinternal medicine and geriatric wardDose-Response Relationshipolder patientRisk Factorsoral anticoagulant80 and overHumansatrial fibrillationPharmacology (medical)Prospective StudiesAgedRetrospective StudiesAged 80 and overPharmacologygeriatric wardsDose-Response Relationship DrugSettore MED/09 - MEDICINA INTERNAAge FactorsAnticoagulantsinternal medicine and geriatric wardsOriginal Articlesolder patientsappropriateness of prescription; atrial fibrillation; internal medicine and geriatric wards; older patients; oral anticoagulant;appropriateness of prescription; atrial fibrillation; internal medicine and geriatric wards; older patients; oral anticoagulant; Pharmacology; Pharmacology (medical)Strokeinternal medicineappropriateness of prescription; atrial fibrillation; internal medicine and geriatric wards; older patients; oral anticoagulantAdministrationFemaleDrug
researchProduct

Drug Prescription and Delirium in Older Inpatients: Results From the Nationwide Multicenter Italian Delirium Day 2015-2016

2019

Objective This study aimed to evaluate the association between polypharmacy and delirium, the association of specific drug categories with delirium, and the differences in drug-delirium association between medical and surgical units and according to dementia diagnosis. Methods Data were collected during 2 waves of Delirium Day, a multicenter delirium prevalence study including patients (aged 65 years or older) admitted to acute and long-term care wards in Italy (2015-2016); in this study, only patients enrolled in acute hospital wards were selected (n = 4,133). Delirium was assessed according to score on the 4 "A's" Test. Prescriptions were classified by main drug categories; polypharmacy w…

Malediagnosismedications0302 clinical medicinepreventionAged 80 and over; Delirium; Drug Prescriptions; Female; Hospital Departments; Humans; Male; Prevalence; Polypharmacy; Prescription Drugs80 and overPrevalenceMedicineLS4_4030212 general & internal medicineAcute hospitalmedia_commonAged 80 and overConfoundingelderly patients hip fracture hospitalized patients prediction rule risk factor dementia events medications prevention diagnosisrisk-factorrisk factorhip fracturePsychiatry and Mental HealthFemalemedicine.symptomeventsDrugmedicine.medical_specialtyPrescription Drugshospitalized-patientsmedia_common.quotation_subjectMEDLINEHospital DepartmentsSocio-culturaleelderly-patientselderly patientsbehavioral disciplines and activitiesDrug Prescriptions03 medical and health sciencesInternal medicinemental disordersDementiaHumansMedical prescriptionprediction ruleAgedPolypharmacybusiness.industryhospitalized patientsDeliriummedicine.diseasenervous system diseasesPolypharmacyDeliriumelderly-patients; hip fracture; hospitalized-patients; prediction rule; risk-factor; dementia; events; medications; prevention; diagnosisbusiness030217 neurology & neurosurgerydementia
researchProduct

"Delirium Day": a nationwide point prevalence study of delirium in older hospitalized patients using an easy standardized diagnostic tool

2016

Background To date, delirium prevalence in adult acute hospital populations has been estimated generally from pooled findings of single-center studies and/or among specific patient populations. Furthermore, the number of participants in these studies has not exceeded a few hundred. To overcome these limitations, we have determined, in a multicenter study, the prevalence of delirium over a single day among a large population of patients admitted to acute and rehabilitation hospital wards in Italy. Methods This is a point prevalence study (called “Delirium Day”) including 1867 older patients (aged 65 years or more) across 108 acute and 12 rehabilitation wards in Italian hospitals. Delirium wa…

MaleCross-sectional studyHospitalized patientsPrevalence0302 clinical medicineSurveys and Questionnaires80 and overOdds RatioPrevalenceMedicine030212 general & internal medicineProspective StudiesProspective cohort studyMulticenterAcute hospital2. Zero hungerAged 80 and overMedicine(all)Medicine (all)Settore BIO/14General Medicine3. Good health4AT; Delirium; Hospital; Multicenter; Prevalence; Aged; Aged 80 and over; Cross-Sectional Studies; Delirium; Female; Humans; Inpatients; Italy; Logistic Models; Male; Odds Ratio; Prevalence; Prospective Studies; Surveys and QuestionnairesItalyFemalemedicine.symptomResearch ArticleRehabilitation hospitalmedicine.medical_specialty4AT; Delirium; Hospital; Multicenter; Prevalence; Aged; Aged 80 and over; Cross-Sectional Studies; Delirium; Female; Humans; Inpatients; Italy; Logistic Models; Male; Odds Ratio; Prevalence; Prospective Studies; Surveys and Questionnaires; Medicine (all)NO03 medical and health sciencesHospital4AT Delirium Hospital Multicenter Prevalence Aged Aged 80 and over Cross-Sectional Studies Delirium Female Humans Inpatients Italy Logistic Models Male Odds Ratio Prevalence Prospective Studies Surveys and Questionnairesmental disordersHumans4ATPsychiatry4AT; Delirium; Hospital; Multicenter; Prevalence;AgedInpatientsbusiness.industryDeliriumOdds ratio4AT; Delirium; Hospital; Multicenter; Prevalence; Medicine (all)Cross-Sectional StudiesLogistic ModelsEmergency medicineDeliriumDelirium; Prevalence; Hospital; Multicenter; 4ATbusiness030217 neurology & neurosurgery
researchProduct

Vascular Risk Factors in Mild Cognitive Impairment Subtypes

2007

<i>Background and Aim:</i> To investigate the role of vascular risk factors in different subtypes of mild cognitive impairment (MCI) in a multicentric, clinic-based, cross-sectional study. <i>Methods:</i> Two-hundred and seven subjects with MCI were included in the study: 33 with single non-memory MCI (snmMCI), 42 with multiple-domain amnestic MCI (mdMCI-a) and 132 with amnestic MCI (aMCI). Several clinical vascular risk factors and magnetic resonance imaging (MRI) brain lesions were evaluated. <i>Results:</i> snmMCI showed a higher frequency of ischaemic heart disease and of transient ischaemic attack (TIA)/stroke, a higher Hachinski ischaemic score and …

vasculopatia cerebralemedicine.medical_specialtymild cognitive impairment; demenza; vasculopatia cerebraleCognitive Neurosciencebehavioral disciplines and activitiesWhite matterDegenerative diseasemild cognitive impairmentInternal medicinemental disordersmedicineDementiaRisk factorPsychiatryStrokemedicine.diagnostic_testCognitive disorderMagnetic resonance imagingmedicine.diseaseHyperintensitynervous system diseasesPsychiatry and Mental healthmedicine.anatomical_structureCardiologydemenzaGeriatrics and GerontologyPsychology
researchProduct