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RESEARCH PRODUCT

Vascular Risk Factors in Mild Cognitive Impairment Subtypes

E. MarianiR. MonasteroS. ErcolaniF. MangialascheM. CaputoF. T. FelizianiD. F. VitaleU. SeninP. Mecocci Among Regal Project ComponentsPatrizio Odetti

subject

vasculopatia cerebralemedicine.medical_specialtymild cognitive impairment; demenza; vasculopatia cerebraleCognitive Neurosciencebehavioral disciplines and activitiesWhite matterDegenerative diseasemild cognitive impairmentInternal medicinemental disordersmedicineDementiaRisk factorPsychiatryStrokemedicine.diagnostic_testCognitive disorderMagnetic resonance imagingmedicine.diseaseHyperintensitynervous system diseasesPsychiatry and Mental healthmedicine.anatomical_structureCardiologydemenzaGeriatrics and GerontologyPsychology

description

<i>Background and Aim:</i> To investigate the role of vascular risk factors in different subtypes of mild cognitive impairment (MCI) in a multicentric, clinic-based, cross-sectional study. <i>Methods:</i> Two-hundred and seven subjects with MCI were included in the study: 33 with single non-memory MCI (snmMCI), 42 with multiple-domain amnestic MCI (mdMCI-a) and 132 with amnestic MCI (aMCI). Several clinical vascular risk factors and magnetic resonance imaging (MRI) brain lesions were evaluated. <i>Results:</i> snmMCI showed a higher frequency of ischaemic heart disease and of transient ischaemic attack (TIA)/stroke, a higher Hachinski ischaemic score and a higher frequency of white-matter lesions on MRI compared to aMCI. Subjects with mdMCI-a showed clinical characteristics similar to aMCI, except for a higher frequency of a history of TIA/stroke. <i>Conclusion:</i> Our findings suggest that snmMCI may be considered a vascular cognitive disorder.

yearjournalcountryeditionlanguage
2007-01-01
10.1159/000110653http://hdl.handle.net/11567/325705