0000000000407002

AUTHOR

Roukayatou Mbouangouere

showing 3 related works from this author

A new ceramide from the leaves of Lannea schimperi (Hochst. ex A.Rich.) Engl.

2020

A new ceramide is being reported herein together with six known compounds from the methanol extract of the leaves of Lannea schimperi (Hochst. ex A.Rich.) Engl. The metabolites were obtained through repeated open column chromatography and were characterized by spectroscopic and spectrometric techniques. The radical-scavenging activity of the crude extract and isolated compounds was evaluated using the DPPH radical. The obtained results suggest the studied species as prominent candidate to fight reactive oxygen species (ROS).

chemistry.chemical_classificationReactive oxygen speciesCeramideChromatographybiology010405 organic chemistryDPPHOrganic ChemistryPlant Sciencebiology.organism_classification01 natural sciencesBiochemistry0104 chemical sciencesAnalytical Chemistry010404 medicinal & biomolecular chemistrychemistry.chemical_compoundColumn chromatographychemistryLannea schimperiAnacardiaceaeMethanolNatural Product Research
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A naturally occuring triterpene saponin ardisiacrispin B displayed cytotoxic effects in multi-factorial drug resistant cancer cells via ferroptotic a…

2018

WOS: 000432722700010

0301 basic medicineProgrammed cell deathCytotoxicitySaponinPharmaceutical ScienceApoptosisFlow cytometryCell Cycle Distribution03 medical and health sciencesArdisiacrispin BCell Line TumorDrug DiscoverymedicineFerroptosisHumansCytotoxic T cellOleanolic AcidCytotoxicityCaspaseMembrane Potential MitochondrialPharmacologybiologymedicine.diagnostic_testMitochondrial Membrane PotentialChemistryHep G2 CellsSaponinsHCT116 Cellsmedicine.diseaseAntineoplastic Agents PhytogenicDrug Resistance MultipleLeukemia030104 developmental biologyComplementary and alternative medicineDoxorubicinDrug Resistance NeoplasmApoptosisCaspasesCancer cellbiology.proteinCancer researchMolecular MedicineReactive Oxygen SpeciesPhytomedicine
researchProduct

A new ceramide from the leaves of Lannea schimperi (Hochst. ex A.Rich.) Engl.

2020

A new ceramide is being reported herein together with six known compounds from the methanol extract of the leaves of Lannea schimperi (Hochst. ex A.Rich.) Engl. The metabolites were obtained through repeated open column chromatography and were characterized by spectroscopic and spectrometric techniques. The radical-scavenging activity of the crude extract and isolated compounds was evaluated using the DPPH radical. The obtained results suggest the studied species as prominent candidate to fight reactive oxygen species (ROS).

researchProduct