0000000000408643

AUTHOR

Silvia De Santis

0000-0001-9739-6926

showing 2 related works from this author

Characterizing microstructural tissue properties in multiple sclerosis with diffusion MRI at 7 T and 3 T: The impact of the experimental design

2019

The recent introduction of advanced magnetic resonance (MR) imaging techniques to characterize focal and global degeneration in multiple sclerosis (MS), like the Composite Hindered and Restricted Model of Diffusion, or CHARMED, diffusional kurtosis imaging (DKI) and Neurite Orientation Dispersion and Density Imaging (NODDI) made available new tools to image axonal pathology non-invasively in vivo. These methods already showed greater sensitivity and specificity compared to conventional diffusion tensor-based metrics (e.g., fractional anisotropy), overcoming some of its limitations. While previous studies uncovered global and focal axonal degeneration in MS patients compared to healthy contr…

0301 basic medicineTime FactorsUltra-high field MRIAxonal pathologyCohort Studies0302 clinical medicineNuclear magnetic resonancemethods [Diffusion Magnetic Resonance Imaging]MicrostructureNODDImedicine.diagnostic_testGeneral NeuroscienceWATER DIFFUSIONmedicine.anatomical_structureResearch DesignKurtosisMulti-shell diffusion MRIAxonal degenerationWHITE-MATTERTENSORAdultMaterials sciencetherapy [Multiple Sclerosis]Sensitivity and SpecificityWhite matterMultiple sclerosis03 medical and health sciencesFractional anisotropyImage Interpretation Computer-Assistedmedicinediagnostic imaging [Nerve Degeneration]Journal ArticleHumansddc:610OPTIMIZATIONMultiple sclerosisinstrumentation [Diffusion Magnetic Resonance Imaging]diagnostic imaging [Multiple Sclerosis]Magnetic resonance imagingQUANTIFICATIONmedicine.diseaseMODELPATHOLOGYDiffusion Magnetic Resonance Imaging030104 developmental biologyRESOLUTIONDENSITYNerve Degeneration030217 neurology & neurosurgeryDiffusion MRI
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Gray matter network reorganization in multiple sclerosis from 7‐Tesla and 3‐Tesla MRI data

2020

[Objective]: The objective of this study was to determine the ability of 7T‐MRI for characterizing brain tissue integrity in early relapsing‐remitting MS patients compared to conventional 3T‐MRI and to investigate whether 7T‐MRI improves the performance for detecting cortical gray matter neurodegeneration and its associated network reorganization dynamics.

AdultMaleDYNAMICS0301 basic medicineNeurosciences. Biological psychiatry. NeuropsychiatryBrain tissueATROPHYYoung Adult03 medical and health sciencesMultiple Sclerosis Relapsing-Remitting0302 clinical medicineText miningAtrophymedicineHumans3 TGray MatterRC346-429Research ArticlesCerebral CortexCHALLENGESbusiness.industryDISABILITYGeneral NeuroscienceMultiple sclerosisMiddle AgedTissue repairmedicine.diseaseMagnetic Resonance ImagingWhite Matter030104 developmental biologyHealthy individualsFemaleNeurology. Diseases of the nervous systemNeurology (clinical)Nerve NetbusinessNuclear medicine030217 neurology & neurosurgeryRC321-571Research ArticleAnnals of Clinical and Translational Neurology
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