0000000000409119
AUTHOR
Nicolas Navoret
Recurrence quantification analysis as a tool for complex fractionated atrial electrogram discrimination
International audience; Atrial fibrillation is the most encountered pathology of the heart rate. The reasons of its occurrence and its particular characteristics remain unknown, resulting from complex phenomena interaction. From these interactions emerges Complex Fractionated Atrial Electrograms (CFAE) which are useful for the ablation procedure. This study presents a method based on nonlinear data analysis, the Recurrence Quantification Analysis (RQA) applied on intracardiac atrial electrograms to detect CFAE particularities. The results obtained on areas previously tagged by a cardilogist show a good sensitivity to CFAE. Combination of RQA features offers a larger discrimination potential…
Relationship between complex fractionated atrial electrogram patterns and different heart substrate configurations
International audience; Complex Fractionated Atrial Electrograms (CFAE) were identified as being symptomatic of reentrant activities. Signals recorded by an intracardiac catheter give an imprecise vision of the underlying phenomena that occur in the proarrhythmic substrate. In this study, phenomenological and ionic numerical models were used to simulate a small piece of the atrium substrate. The catheter measurement is also simulated numerically to take into account electrode particularities. Modifications were applied on the numerical substrate. Then stimulation scenarios were generated in the numerical substrate such as planar waves, stable or breaking spirals. Comparison between simulate…
Comparison of complex fractionated atrial electrograms at cellular scale using numerical and experimental models.
This study investigates the existence of the pseudo complex fractionated atrial electrogram (CFAE) at cellular level. Our assumptions are based on the fact that CFAEs are linked to the generation of the spiral waves. These are created using a numerical model and an experimental model of in vitro culture of neonatal rats cardiac cells. Pseudo bipolar electrograms resulting from these two models are compared qualitatively and some patterns could be identified as CFAE signature.