0000000000413725

AUTHOR

Martin R. Müller

showing 2 related works from this author

Dependence on nuclear factor of activated T-cells (NFAT) levels discriminates conventional T cells from Foxp3 + regulatory T cells

2012

Several lines of evidence suggest nuclear factor of activated T-cells (NFAT) to control regulatory T cells: thymus-derived naturally occurring regulatory T cells (nTreg) depend on calcium signals, the Foxp3 gene harbors several NFAT binding sites, and the Foxp3 (Fork head box P3) protein interacts with NFAT. Therefore, we investigated the impact of NFAT on Foxp3 expression. Indeed, the generation of peripherally induced Treg (iTreg) by TGF-β was highly dependent on NFAT expression because the ability of CD4 + T cells to differentiate into iTreg diminished markedly with the number of NFAT family members missing. It can be concluded that the expression of Foxp3 in TGF-β–induced iTreg depends…

Chromatin ImmunoprecipitationAdoptive cell transferT-LymphocytesImmunoblottingFluorescent Antibody TechniqueLymphocyte ActivationT-Lymphocytes RegulatoryAutoimmune DiseasesProinflammatory cytokineMiceTransforming Growth Factor betaAnimalsHumansHomeodomain ProteinsMultidisciplinaryNFATC Transcription FactorsbiologyFOXP3Forkhead Transcription FactorsNFATTransforming growth factor betaBiological SciencesColitisFlow CytometryNFATC Transcription FactorsAdoptive TransferMolecular biologyCell biologyTransplantationCyclosporinebiology.proteinChromatin immunoprecipitationProceedings of the National Academy of Sciences
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NFATc1 affects mouse splenic B cell function by controlling the calcineurin–NFAT signaling network

2011

Mouse B cells lacking NFATc1 exhibit defective proliferation, survival, isotype class switching, cytokine production, and T cell help.

T-LymphocytesImmunologyNaive B cellB-cell receptorReceptors Antigen B-CellLymphocyte ActivationArticleMice03 medical and health sciences0302 clinical medicinemedicineAnimalsImmunology and AllergyB cell030304 developmental biologyB-Lymphocytes0303 health sciencesCD40NFATC Transcription Factorsintegumentary systembiologyCalcineurinCD22Germinal centerImmunoglobulin Class SwitchingMolecular biology3. Good healthB-1 cellCalcineurinmedicine.anatomical_structure030220 oncology & carcinogenesisCancer researchbiology.proteinCalciumSpleenSignal TransductionJournal of Experimental Medicine
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