NFATc1 affects mouse splenic B cell function by controlling the calcineurin–NFAT signaling network

6533b821fe1ef96bd127ae61

RESEARCH PRODUCT

NFATc1 affects mouse splenic B cell function by controlling the calcineurin–NFAT signaling network

Swen Engelmann Ursula Bommhardt Duong Anh Thuy Pham Lars Nitschke Astrid Schweizer Kurt Reifenberg Andreas Rosenwald Cornelia Brunner Martin Vaeth Edward D. Lamperti Martin R. Müller Andris Avots Sankar Bhattacharyya Wen Chen Julia Jellusova Amiya K. Patra Eisaku Kondo Edgar Serfling Friederike Berberich-siebelt Jolly Deb Stefan Klein-hessling Ellen Leich

subject

T-Lymphocytes Immunology Naive B cell B-cell receptor Receptors Antigen B-Cell Lymphocyte Activation Article Mice 03 medical and health sciences 0302 clinical medicine medicine Animals Immunology and Allergy B cell 030304 developmental biology B-Lymphocytes 0303 health sciences CD40 NFATC Transcription Factors integumentary system biology Calcineurin CD22 Germinal center Immunoglobulin Class Switching Molecular biology 3. Good health B-1 cell Calcineurin medicine.anatomical_structure 030220 oncology & carcinogenesis Cancer research biology.protein Calcium Spleen Signal Transduction

description

Mouse B cells lacking NFATc1 exhibit defective proliferation, survival, isotype class switching, cytokine production, and T cell help.

year	journal	country	edition	language
2011-04-04	Journal of Experimental Medicine

https://doi.org/10.1084/jem.20100945

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